Single-cell transcriptomics for cardiomyocytes of human hypertrophic cardiomyopathy
Release date:
2021-03-31
Description:
Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease. In this study, we performed single-cell RNA-sequencing (scRNA-seq) of 2,115 individual cardiomyocytes obtained from HCM patients (n = 7) and normal controls (n = 2). We identified a large number of genes significantly upregulated in HCM cardiomyocytes, which including genes regulating muscle contraction or relaxation and genes responding to growth factors. Interestingly, the upregulated genes also included typical fibroblast markers and extracellular matrix genes.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.