Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

URL: https://idrblab.org/intede/
Full name: Interactome of Drug-metabolizing Enzymes
Description: Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and the interactome of DMEs has attracted extensive attention. There are 3 major interaction types in an interactome: microbiome-DME interaction (MICBIO), xenobiotics-DME interaction (XEOTIC), and host protein-DME interaction (HOSPPI). The interaction data of each type are essential for drug metabolism, and the collective consideration of multiple types has implication for the future practice of precision medicine. However, no database was designed to systematically provide the data of all types of DME interactions. Here, a database of the Interactome of Drug-Metabolizing Enzymes (INTEDE) was therefore constructed to offer these interaction data. First, 1,047 unique DMEs (448 host and 599 microbial) were confirmed, for the first time, using their metabolizing drugs. Second, for these newly confirmed DMEs, all types of their interactions (3,359 MICBIOs between 225 microbial species and 185 DMEs; 47,778 XEOTICs between 4,150 xenobiotics and 501 DMEs; 7,849 HOSPPIs between 565 human proteins and 566 DMEs) were comprehensively collected and then provided, which enabled the crosstalk analysis among multiple types. Because of the huge amount of accumulated data, the INTEDE made it possible to generalize key features for revealing disease etiology and optimizing clinical treatment. INTEDE is freely accessible at: https://idrblab.org/intede/.
Year founded: 2020
Last update:
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Country/Region: China
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Contact information

University/Institution: Zhejiang University
Address: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
City: Hangzhou
Province/State: Zhejiang
Country/Region: China
Contact name (PI/Team): Zhu Feng
Contact email (PI/Helpdesk): zhufeng@zju.edu.cn

Publications

33045737
INTEDE: interactome of drug-metabolizing enzymes. [PMID: 33045737]
Jiayi Yin, Fengcheng Li, Ying Zhou, Minjie Mou, Yinjing Lu, Kangli Chen, Jia Xue, Yongchao Luo, Jianbo Fu, Xu He, Jianqing Gao, Su Zeng, Lushan Yu, Feng Zhu

Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and the interactome of DMEs has attracted extensive attention. There are 3 major interaction types in an interactome: microbiome-DME interaction (MICBIO), xenobiotics-DME interaction (XEOTIC) and host protein-DME interaction (HOSPPI). The interaction data of each type are essential for drug metabolism, and the collective consideration of multiple types has implication for the future practice of precision medicine. However, no database was designed to systematically provide the data of all types of DME interactions. Here, a database of the Interactome of Drug-Metabolizing Enzymes (INTEDE) was therefore constructed to offer these interaction data. First, 1047 unique DMEs (448 host and 599 microbial) were confirmed, for the first time, using their metabolizing drugs. Second, for these newly confirmed DMEs, all types of their interactions (3359 MICBIOs between 225 microbial species and 185 DMEs; 47 778 XEOTICs between 4150 xenobiotics and 501 DMEs; 7849 HOSPPIs between 565 human proteins and 566 DMEs) were comprehensively collected and then provided, which enabled the crosstalk analysis among multiple types. Because of the huge amount of accumulated data, the INTEDE made it possible to generalize key features for revealing disease etiology and optimizing clinical treatment. INTEDE is freely accessible at: https://idrblab.org/intede/.

Nucleic Acids Res. 2020:() | 2 Citations (from Europe PMC, 2021-05-01)

Ranking

All databases:
2711/5030 (46.123%)
Interaction:
441/763 (42.333%)
Health and medicine:
561/1056 (46.97%)
2711
Total Rank
2
Citations
2
z-index

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Record metadata

Created on: 2020-11-13
Curated by:
lin liu [2021-03-24]
Dong Zou [2020-11-19]
Zhan Zhou [2020-11-13]