Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

URL: http://cadd.zju.edu.cn/protacdb/
Full name: Proteolysis-targeting chimeras database
Description: A web-based open-access database that integrates structural information and experimental data of Proteolysis-targeting chimeras (PROTACs). PROTAC-DB consists of 1662 PROTACs, 202 warheads (small molecules that target the proteins of interest), 65 E3 ligands (small molecules capable of recruiting E3 ligases) and 806 linkers, as well as their chemical structures, biological activities, and physicochemical properties.
Year founded: 2020
Last update:
Version:
Accessibility:
Manual:
Accessible
Real time : Checking...
Country/Region: China
Data type:
Data object:
NA
Database category:
Major organism:
NA
Keywords:

Contact information

University/Institution: Zhejiang University
Address: Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences,Zhejiang University, Hangzhou 310058, Zhejiang, China
City: Hangzhou
Province/State: Zhejiang
Country/Region: China
Contact name (PI/Team): Tingjun Hou
Contact email (PI/Helpdesk): tingjunhou@zju.edu.cn

Publications

33010159
PROTAC-DB: an online database of PROTACs. [PMID: 33010159]
Gaoqi Weng, Chao Shen, Dongsheng Cao, Junbo Gao, Xiaowu Dong, Qiaojun He, Bo Yang, Dan Li, Jian Wu, Tingjun Hou

Proteolysis-targeting chimeras (PROTACs), which selectively degrade targeted proteins by the ubiquitin-proteasome system, have emerged as a novel therapeutic technology with potential advantages over traditional inhibition strategies. In the past few years, this technology has achieved substantial progress and two PROTACs have been advanced into phase I clinical trials. However, this technology is still maturing and the design of PROTACs remains a great challenge. In order to promote the rational design of PROTACs, we present PROTAC-DB, a web-based open-access database that integrates structural information and experimental data of PROTACs. Currently, PROTAC-DB consists of 1662 PROTACs, 202 warheads (small molecules that target the proteins of interest), 65 E3 ligands (small molecules capable of recruiting E3 ligases) and 806 linkers, as well as their chemical structures, biological activities, and physicochemical properties. Except the biological activities of warheads and E3 ligands, PROTAC-DB also provides the degradation capacities, binding affinities and cellular activities for PROTACs. PROTAC-DB can be queried with two general searching approaches: text-based (target name, compound name or ID) and structure-based. In addition, for the convenience of users, a filtering tool for the searching results based on the physicochemical properties of compounds is also offered. PROTAC-DB is freely accessible at http://cadd.zju.edu.cn/protacdb/.

Nucleic Acids Res. 2020:() | 2 Citations (from Europe PMC, 2021-02-20)

Ranking

All databases:
2495/4799 (48.031%)
Raw bio-data:
205/475 (57.053%)
Structure:
316/677 (53.471%)
Literature:
164/342 (52.339%)
2495
Total Rank
2
Citations
2
z-index

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Record metadata

Created on: 2020-11-10
Curated by:
lin liu [2021-02-23]
Ruru Chen [2020-11-28]
Chang Liu [2020-11-10]