Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

RefLnc (the human lncRNA atlas)

General information

Description: RefLnc contains a total of 77,900 lncRNAs. Each lncRNA in the atlas is characterized by a panorama of sequence, expression and trait association. The genome-wide lncRNA expression is profiled based on a compendium of 14,166 RNA-Seq libraries from 30 physiological tissues, 18 tumors and two cell lines from two independent data sets.
Year founded: 2017
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Country/Region: China
Data type:
RNA
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Contact information

University/Institution: Peking University
Address:
City: Beijing
Province/State:
Country/Region: China
Contact name (PI/Team): Ge Gao
Contact email (PI/Helpdesk): gaog@mail.cbi.pku.edu.cn

Related Database

Record metadata

Created on: 2020-02-13
Curated by:
Lina Ma [2020-02-13]

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Publications

31350901
An expanded landscape of human long noncoding RNA. [PMID: 31350901]
Jiang S, Cheng SJ, Ren LC, Wang Q, Kang YJ, Ding Y, Hou M, Yang XX, Lin Y, Liang N, Gao G.

Long noncoding RNAs (lncRNAs) are emerging as key regulators of multiple essential biological processes involved in physiology and pathology. By analyzing the largest compendium of 14,166 samples from normal and tumor tissues, we significantly expand the landscape of human long noncoding RNA with a high-quality atlas: RefLnc (Reference catalog of LncRNA). Powered by comprehensive annotation across multiple sources, RefLnc helps to pinpoint 275 novel intergenic lncRNAs correlated with sex, age or race as well as 369 novel ones associated with patient survival, clinical stage, tumor metastasis or recurrence. Integrated in a user-friendly online portal, the expanded catalog of human lncRNAs provides a valuable resource for investigating lncRNA function in both human biology and cancer development.

Nucleic Acids Res. 2019:47(15) | 0 Citations (from Europe PMC, 2020-05-23)