a catalog of biological databases
|Description:||RefLnc contains a total of 77,900 lncRNAs. Each lncRNA in the atlas is characterized by a panorama of sequence, expression and trait association. The genome-wide lncRNA expression is profiled based on a compendium of 14,166 RNA-Seq libraries from 30 physiological tissues, 18 tumors and two cell lines from two independent data sets.|
|Contact name (PI/Team):||Ge Gao|
|Contact email (PI/Helpdesk):||email@example.com|
An expanded landscape of human long noncoding RNA. [PMID: 31350901]
Long noncoding RNAs (lncRNAs) are emerging as key regulators of multiple essential biological processes involved in physiology and pathology. By analyzing the largest compendium of 14,166 samples from normal and tumor tissues, we significantly expand the landscape of human long noncoding RNA with a high-quality atlas: RefLnc (Reference catalog of LncRNA). Powered by comprehensive annotation across multiple sources, RefLnc helps to pinpoint 275 novel intergenic lncRNAs correlated with sex, age or race as well as 369 novel ones associated with patient survival, clinical stage, tumor metastasis or recurrence. Integrated in a user-friendly online portal, the expanded catalog of human lncRNAs provides a valuable resource for investigating lncRNA function in both human biology and cancer development.