a catalog of biological databases
|Description:||Chinese Genomic Variation Database (CGVD) is designed to widely collect curated genomic variations in Chinese populations and to comprehensively integrate the annotations on biology functions, pharmacogenomics, phenotype and disease associations.|
|University/Institution:||Beijing Institute of Genomics, Chinese Academy of Sciences|
|Address:||Beijing Institute of Genomics, Chinese Academy of Sciences No.1 Beichen West Road, Chaoyang District|
|Contact name (PI/Team):||Jingfa Xiao|
|Contact email (PI/Helpdesk):||CGVD@big.ac.cn|
CGVD: a genomic variation database for Chinese populations. [PMID: 31665422]
Precision medicine calls upon deeper coverage of population-based sequencing and thorough gene-content and phenotype-based analysis, which lead to a population-associated genomic variation map or database. The Chinese Genomic Variation Database (CGVD; https://bigd.big.ac.cn/cgvd/) is such a database that has combined 48.30 million (M) SNVs and 5.77 M small indels, identified from 991 Chinese individuals of the Chinese Academy of Sciences Precision Medicine Initiative Project (CASPMI) and 301 Chinese individuals of the 1000 Genomes Project (1KGP). The CASPMI project includes whole-genome sequencing data (WGS, 25-30×) from ∼1000 healthy individuals of the CASPMI cohort. To facilitate the usage of such variations for pharmacogenomics studies, star-allele frequencies of the drug-related genes in the CASPMI and 1KGP populations are calculated and provided in CGVD. As one of the important database resources in BIG Data Center, CGVD will continue to collect more genomic variations and to curate structural and functional annotations to support population-based healthcare projects and studies in China and worldwide.