Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

DSMNC (Somatic SNVs occurring in single cells from various human and mouse)

General information

Description: DSMNC is a database which provides most comprehensive catalogue of somatic SNVs occurring in single cells from various human and mouse normal tissues.
Year founded: 2018
Last update: 2018
Version:
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Country/Region: China
Data type:
DNA
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Contact information

University/Institution: Beijing Institute of Genomics, Chinese Academy of Sciences
Address: No.1 Beichen West Road, Chaoyang District
City: Beijing
Province/State: Beijing
Country/Region: China
Contact name (PI/Team): Jun Cai
Contact email (PI/Helpdesk): juncai@big.ac.cn

Related Database

Record metadata

Created on: 2019-01-03
Curated by:
Dong Zou [2019-12-03]
Dong Zou [2019-09-09]
Dong Zou [2019-01-10]
Dong Zou [2019-01-03]

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Publications

30380071
DSMNC: a database of somatic mutations in normal cells. [PMID: 30380071]
Miao X, Li X, Wang L, Zheng C, Cai J.

Numerous non-inherited somatic mutations, distinct from those of germ-line origin, occur in somatic cells during DNA replication per cell-division. The somatic mutations, recording the unique genetic cell-lineage 'history' of each proliferating normal cell, are important but remain to be investigated because of their ultra-low frequency hidden in the genetic background of heterogeneous cells. Luckily, the recent development of single-cell genomics biotechnologies enables the screening and collection of the somatic mutations, especial single nucleotide variations (SNVs), occurring in normal cells. Here, we established DSMNC: a database of somatic mutations in normal cells (http://dsmnc.big.ac.cn/), which provides most comprehensive catalogue of somatic SNVs in single cells from various normal tissues. In the current version, the database collected ?0.8 million SNVs accumulated in ?600 single normal cells (579 human cells and 39 mouse cells). The database interface supports the user-friendly capability of browsing and searching the SNVs and their annotation information. DSMNC, which serves as a timely and valuable collection of somatic mutations in individual normal cells, has made it possible to analyze the burdens and signatures of somatic mutations in various types of heterogeneous normal cells. Therefore, DSMNC will significantly improve our understanding of the characteristics of somatic mutations in normal cells.

Nucleic Acids Res. 2019:47(D1) | 1 Citations (from Europe PMC, 2020-08-01)