Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

AlzBase (an integrative database for gene dys-regulation in Alzheimer’s disease)

General information

Description: AlzBase provides four types of information regarding genes involved in Alzheimer’s disease (AD): 1) Gene dys-regulation in AD, aging and related diseases. 2) Multi-level annotations including correlation to AD severity. 3) Gene networks including brain co-expression network. 4) A summary of top genes in Alzbase and those from genetic studies of AD.
Year founded: 2014
Last update: 2014-08-30
Version: 1.0
Accessibility:
Manual:
Accessible
Real time : Checking...
Country/Region: China
Data type:
DNA
Data object:
Database category:
Major organism:
Keywords:

Contact information

University/Institution: Beijing Institute of Genomics, Chinese Academy of Sciences
Address: No.1 Beichen West Road, Chaoyang District
City: Beijing
Province/State:
Country/Region: China
Contact name (PI/Team): Hongxing Lei
Contact email (PI/Helpdesk): leihx@big.ac.cn

Record metadata

Created on: 2016-05-06
Curated by:
Dong Zou [2018-03-08]
Zhang Zhang [2016-05-24]
Lina Ma [2016-05-14]
Zhang Zhang [2016-05-08]

Ranking

All databases:
2364/4692 (49.638%)
Health and medicine:
461/959 (52.033%)
Expression:
463/843 (45.196%)
Interaction:
388/698 (44.556%)
2364
Total Rank
9
Citations
2.25
z-index

Community reviews

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Publications

25432889
AlzBase: an Integrative Database for Gene Dysregulation in Alzheimer's Disease. [PMID: 25432889]
Bai Z, Han G, Xie B, Wang J, Song F, Peng X, Lei H.

Alzheimer's disease (AD) affects a significant portion of elderly people worldwide. Although the amyloid-? (A?) cascade hypothesis has been the prevailing theory for the molecular mechanism of AD in the past few decades, treatment strategies targeting the A? cascade have not demonstrated effectiveness as yet. Thus, elucidating the spatial and temporal evolution of the molecular pathways in AD remains to be a daunting task. To facilitate novel discoveries in this filed, here, we have integrated information from multiple sources for the better understanding of gene functions in AD pathogenesis. Several categories of information have been collected, including (1) gene dysregulation in AD and closely related processes/diseases such as aging and neurological disorders, (2) correlation of gene dysregulation with AD severity, (3) a wealth of annotations on the functional and regulatory information, and (4) network connections for gene-gene relationship. In addition, we have also provided a comprehensive summary for the top ranked genes in AlzBase. By evaluating the information curated in AlzBase, researchers can prioritize genes from their own research and generate novel hypothesis regarding the molecular mechanism of AD. To demonstrate the utility of AlzBase, we examined the genes from the genetic studies of AD. It revealed links between the upstream genetic variations and downstream endo-phenotype and suggested several genes with higher priority. This integrative database is freely available on the web at http://alz.big.ac.cn/alzBase.

Mol Neurobiol. 2016:53(1) | 9 Citations (from Europe PMC, 2020-09-19)