PMID Title Journal Year Gene Symbol Citation
16530701 Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of diseaseprogression, and resemble stages in neurogenesis. Cancer Cell 2006 PTEN
DLL3
1498
29763623 Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma From the HERBY Phase II Randomized Trial Cancer Cell 2018 CD8
11
22137795 Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 2011 EGFR
MET
PDGFRA
326
25117714 Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursorglioma. Cancer Cell 2015 PDGFA
PTEN
140
24140020 mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metabolism 2013 MTORC2
147
29180699 Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence. Nature Genetics 2018 IDH1
CD24
PDGFRA
27
30343896 Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell 2018 METEX14
PTPRZ1
MET
13
21817013 Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 2011 CIC
FUBP1
256
29763623 Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma From the HERBY Phase II Randomized Trial Cancer Cell 2018 CD8
11
28097324 MoleculaRNABased Recursive Partitioning Analysis Model for Glioblastomain the Temozolomide Era: A Correlative Analysis Based on NRG OncologyRTOG 0525. JAMA Oncology 2018 MGMT
MET
14
29232556 MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell 2017 ATG4B
STK26
24
25151262 Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and gliomasubtypes. Nature Neuroscience 2014 NFIA
SOX10
45
26829751 MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartitemechanism. Nature Genetics 2016 MYB
QKI
69
30742122 Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma Nature Medicine 2019 PD-1
21
28823557 Neural PrecursoRNADerived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. Cell 2017 PTN
21
22820645 Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. Nature Medicine 2012 TRPV1
56
26536111 Brain tumour cells interconnect to a functional and resistant network. Nature 2015 GAP-43
172
24316889 Therapeutic activation of macrophages and microglia to suppress brain tumoRNAinitiating cells. Nature Neuroscience 2014 AMPB
70
25366110 Neuro-oncology: a step towards clinical blood biomarkers of glioblastoma. Nature reviews Neuroscience 2014 YKL-40
GFAP
IGFBP-2
10
23986257 PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients. Journal of Neuro-Oncology 2013 PD-L1
50
22430106 Neuro-oncology: Glioblastoma--community adjusts to new standard of care. Nature reviews Neuroscience 2012 MGMT
2
23817351 Neuro-oncology: in search of molecular markers of glioma in elderly patients. Nature reviews Neuroscience 2013 IDH1
H3F3A
3
23817353 Neuro-oncology: in search of molecular markers of glioma in elderly patients. Nature reviews Neuroscience 2015 APNG
1
23817354 Neuro-oncology: in search of molecular markers of glioma in elderly patients. Nature reviews Neuroscience 2016 PRDX1
4
19498431 Neuro-oncology: Isocitrate dehydrogenase mutations in low-grade gliomas. Nature reviews Neuroscience 2009 IDH1
4
19498432 Neuro-oncology: Isocitrate dehydrogenase mutations in low-grade gliomas. Nature reviews Neuroscience 2010 IDH2
45
28263309 EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nature medicine 2017 EZH2
78
24435880 A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro-Oncology 2014 hsa-mir-320
hsa-mir-574-3p
110
23917401 The integrated landscape of driver genomic alterations in glioblastoma. Cancer Cell 2013 LZTR1
CTNND2
EGFR
SEPT14
182
25140036 TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. Neuro-Oncology 2015 TERT
51
25050814 A unique fouRNAhub protein cluster associates to glioblastoma progression. PLoS One 2014 Huntingtin
HNF4A
MYC
IDH3A
11
24061435 Neuro-oncology: The long and winding road--gene therapy for glioma. Nature reviews Neuroscience 2013 HSV-Tk
5
25822375 Treatment of elderly patients with glioblastoma: a systematic evidence-based analysis. JAMA Neurology 2015 MGMT
26
23147854 Neuro-oncology: treatment decisions in elderly patients with glioblastoma. Nature reviews Neuroscience 2012 MGMT
9
20531430 Neuro-oncology: unmasking the multiforme in glioblastoma. Nature reviews Neuroscience 2010 MGMT
IDH1
IDH2
PDGFR
EGFR
4
21811295 The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. Nature reviews Neuroscience 2011 NOTCH1
CD133
GATA6
CEBPB
STAT3
125
21811295 The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. Nature reviews Neuroscience 2011 NOTCH1
CD133
GATA6
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125
28650441 Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. Nature Nanotechnolog 2017 IL-8
TNF
CXCL1/KC
45
19806145 New advances that enable identification of glioblastoma recurrence. Nature Reviews Clinical Oncology 2009 VEGF
BCL2L12
72
29746665 Blood-based Biomarkers for the Diagnosis and Monitoring of Gliomas Neuro-Oncology 2018 EGFRvIII
11
29741745 Prospective Feasibility and Safety Assessment of Surgical Biopsy for Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma Neuro-Oncology 2018 MGMT
EGFR
2
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IDH2
MGMT
ALDH1A3
9
29727797 Visualizing Glioma Margins by Real-Time Tracking of γ-Glutamyltranspeptidase Activity Biomaterials 2018 GGT
6
29662077 Pharmacodynamics of mutant-IDH1 Inhibitors in Glioma Patients Probed by in Vivo 3D MRS Imaging of 2-hydroxyglutarate Nature Communication 2018 IDH1
12
29660021 Mapping of Genomic EGFRvIII Deletions in Glioblastoma: Insight Into Rearrangement Mechanisms and Biomarker Development Neuro-Oncology 2018 EGFRvIII
6
29660019 Modeling the Diffusion of D-2-hydroxyglutarate From IDH1 Mutant Gliomas in the Central Nervous System Neuro-Oncology 2018 IDH1
5
29660006 Validation of Postoperative Residual Contrast-Enhancing Tumor Volume as an Independent Prognostic Factor for Overall Survival in Newly Diagnosed Glioblastoma Neuro-Oncology 2018 MGMT
3
29654229 Somatic Genome Editing With the RCAS-TVA-CRISPRNACas9 System for Precision Tumor Modeling Nature Communication 2018 TP53
CDKN2A
PTEN
BCAN
NTRK1
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6
29635363 Sprouty2 Enhances the Tumorigenic Potential of Glioblastoma Cells Neuro-Oncology 2018 SPRY2
7
29617843 In Vivo Evaluation of EGFRvIII Mutation in Primary Glioblastoma Patients via Complex Multiparametric MRI Signature Neuro-Oncology 2018 EGFRvIII
10
29608290 Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma ACS Nano 2018 HFN
8
29590424 The T2-FLAIR Mismatch Sign as an Imaging Marker for Non-Enhancing IDH-mutant, 1p/19q-intact LoweRNAGrade Glioma: A Validation Study Neuro-Oncology 2018 IDH1
IDH2
5
29558959 Serum Long Noncoding RNA HOTAIR as a Novel Diagnostic and Prognostic Biomarker in Glioblastoma Multiforme Molecular Cancer 2018 HOTAIR
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29532035 Immune Evasion Mediated by PD-L1 on Glioblastoma-Derived Extracellular Vesicles Science Advances 2018 PD-L1
30
29522183 IDH2 mutations are commonly associated with 1p/19q codeletion in diffuse adult gliomas. Neuro-Oncology 2018 IDH1
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29509936 CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges. Neuro-Oncology 2018 IL13
HER2
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29476136 A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nature Communication 2018 PRKCA
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29474647 Females have the survival advantage in glioblastoma. Neuro-Oncology 2018 MGMT
IDH1
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4
27591334 The complex role of transglutaminase 2 in glioblastoma proliferation. Neuro-Oncology 2017 TG2
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27576873 A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses. Neuro-Oncology 2017 VEGF
15
27576873 A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses. Neuro-Oncology 2017 VEGF
15
27576872 Neurocognitive function varies by IDH1 genetic mutation status in patients with malignant glioma prior to surgical resection. Neuro-Oncology 2016 IDH1
17
27571885 Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro-Oncology 2017 IDH1
MGMT
18
27571882 Human TERT promoter mutation enables survival advantage from MGMT promoter methylation in IDH1 wild-type primary glioblastoma treated by standard chemoradiotherapy. Neuro-Oncology 2017 TERT
MGMT
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18
27563106 Response to: "Prognostic relevance of epilepsy at presentation in loweRNAgrade gliomas". Neuro-Oncology 2016 IDH1
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27515827 Evaluation of pseudoprogression rates and tumor progression patterns in a phase III trial of bevacizumab plus radiotherapy/temozolomide for newly diagnosed glioblastoma. Neuro-Oncology 2016 EGFR
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27163161 A Novel TumoRNAPromoting Mechanism of IL6 and the Therapeutic Efficacy of Tocilizumab: Hypoxia-induced IL6 Is a Potent Autophagy Initiator in Glioblastoma via the p-STAT3-MIR155-3p-CREBRF Pathway Autophagy 2016 MIR155-3p
26
27116977 IDH Mutant Gliomas Escape Natural Killer Cell Immune Surveillance by Downregulation of NKG2D Ligand Expression Neuro-Oncology 2016 IDH1
IDH2
34
26957363 Classification Based on Mutations of TERT Promoter and IDH Characterizes Subtypes in Grade II/III Gliomas Neuro-Oncology 2016 TERT
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26881967 Therapeutic Potential of Targeting microRNA-10b in Established Intracranial Glioblastoma: First Steps Toward the Clinic EMBO Molecular Medicine 2016 hsa-mir10b
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29625067 Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression Cell Stem Cell 2018 VEG
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28651374 CD70, a novel target of CAR T-cell therapy for gliomas Neuro-Oncology 2017 CD70
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28605477 MerTK as a Therapeutic Target in Glioblastoma Neuro-Oncology 2017 MerTK 
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31634400 ICOSLG-mediated Regulatory T-cell Expansion and IL-10 Production Promote Progression of Glioblastoma Neuro-Oncology 2020 ICOSLG
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