Accession PRJCA002186
Title ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancer
Relevance Medical
Data types Epigenomics
Transcriptome or Gene expression
Organisms Homo sapiens
Description Low expression of ZIC2 is correlated with poor outcome in breast cancer patients and serves as an independent prognostic marker. Knockdown of ZIC2 promoted tumorigenesis in vitro and in vivo. STAT3 was identified as a potential target for ZIC2 by ChIP-seq and RNA-seq analysis. Inhibiting STAT3 with siRNAs or inhibitors abrogated the oncogenic effects induced by decreased ZIC2, implying that STAT3 inhibitors might provide an alternative option for patients with ZIC2 downregulation.
Sample scope Multiisolate
Release date 2020-02-03
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) General Program 81572600
Submitter Qian    Zhong  (zhongqian@sysucc.org.cn)
Organization Sun Yat-sen University Cancer Center
Submission date 2020-02-03

Project Data

Resource name Description
BioSample (8)  show -
GSA (1) -
CRA002323 ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancer