Accession |
PRJCA002011 |
Title |
Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma |
Relevance |
Medical |
Data types |
Epigenomics
|
Organisms |
Homo sapiens
|
Description |
To investigate the mechanisms and pathways enabling resistance to BRAFi in melanomas, we integrated expression data, ATAC-seq, and CRISPR screen results. Our findings reveal genes whose loss of function conferred resistance to a selective BRAF inhibitor, providing new insight into signaling pathways that contribute to acquired resistance in melanoma. |
Sample scope |
Monoisolate |
Release date |
2019-12-09 |
Publication |
PubMed ID |
Article title |
Journal name |
DOI |
Year |
32413516
|
CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma
|
Genomics, Proteomics & Bioinformatics
|
10.1016/j.gpb.2020.02.002
|
2020
|
|
Grants |
Agency |
program |
Grant ID |
Grant title |
National Natural Science Foundation of China (NSFC)
|
|
81872290
|
|
National Natural Science Foundation of China (NSFC)
|
|
31801185
|
|
|
Submitter |
Binbin
Wang (1610790@tongji.edu.cn)
|
Organization |
Tongji University |
Submission date |
2019-12-09 |