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Accession PRJCA001684
Title gut microbiota in Infants with Cholestasis disease
Relevance Medical
Data types Metagenome
Raw sequence reads
Organisms human gut metagenome
Description Neonatal cholestasis disease (NCD) affects approximately 1 in every 2500 term infants and is infrequently recognized by primary providers in the setting of physiologic jaundice. NCD is mostly due to biliary atresia (BA) and is also frequently resulted from non-BA causes. Developing a non-invasive diagnose method is needing for neonates and their guarder, gut microbiota biomarker and secondary bile acids in the stool may be the best candidates to be utilized to diagnose the NCD. In this investigation, we found microbiota markers which are related to NCD and maybe a non-invasive diagnostic method. Fecal samples of healthy neonates, NCD patients, remission and non-remission patients after around 7 days treating were collected and 16S rRNA genes of them were sequenced by Illumina sequencing platform.
Sample scope Multispecies
Release date 2020-04-26
Publication
PubMed ID Article title Journal name DOI Year
32377002 Gut Microbiota Dysbiosis Associated with Bile Acid Metabolism in Neonatal Cholestasis Disease Scientific Reports 10.1038/s41598-020-64728-4 2020
Grants
Agency program Grant ID Grant title
Key discipline construction project of yunnan province during the 12th five-year plan period 201117
Internal health research institute project in Yunnan Province 2014NS181
Submitter Chuanfa    Liu  (liuchuanfa15@mails.ucas.ac.cn)
Organization Kunming Institute of Zoology, Chinese Academy of Sciences
Submission date 2019-08-20

Project Data

Resource name Description
BioSample (38)  show -
GSA (1) -
CRA001920 gut microbiota of Neonatal cholestasis disease