Accession PRJCA001337
Title Alterations of the human gut microbiota in unraptured intracranial aneurysms
Relevance Medical
Data types Metagenome
Transcriptome or Gene expression
Organisms mouse gut metagenome
Mus musculus
human gut metagenome
Description Unruptured intracranial aneurysms (UIAs) are life-threatening cerebrovascular diseases driven by chronic inflammation. In recent years, significant interest has focused on gut microbiota host interaction because accumulating evidence has revealed that gut microbiota plays a pivotal role in multiple disease. However, whether gut microbiota dysbiosis participates in the development of UIAs remains largely unknown. We performed a metagenome-wide association study in a cohort of 100 UIAs and 100 controls, Chinese individuals. A cohort of 40 UIAs individuals and 40 controls was studied for further validation. Fecal microbiota transplantation from patients to C57BL/6N mice which were pre-treated with antibiotics was conducted to evaluate the role of gut microbiota in contributing to the pathogenesis of UIAs.
Sample scope Multiisolate
Release date 2020-04-23
Publication
PubMed ID Article title Journal name DOI Year
32587239 Alterations of gut microbiota contribute to the progression of unruptured intracranial aneurysms Nature Communications 10.1038/s41467-020-16990-3 2020
Grants
Agency program Grant ID Grant title
National Basic Research Program of China 2014CB541601
CAMS Innovation Fund for Medical Sciences 2016I2M1015
National Natural Science Foundation of China (NSFC) 91539113
National Natural Science Foundation of China (NSFC) 81800263
Submitter Li    Hao  (lihao@bjmu.edu.cn)
Organization Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Submission date 2019-03-20

Project Data

Resource name Description
BioSample (289)  show -
GSA (1) -
CRA001504 Gut microbiota dysbiosis aggravated the profound alterations in the angiotensin II and elastase induced gene transcriptional profile of cerebral vessels