| Accession |
PRJCA001075 |
| Title |
Chromatin accessibility analysis reveals regulatory dynamics of developing human fetal retina |
| Relevance |
Medical |
| Data types |
Epigenomics
Transcriptome or Gene expression
|
| Organisms |
|
| Description |
Dramatic chromatin reorganization occurs during human fetal retinal development. However, how chromatin accessibility governs human retinogenesis remain largely unknown. Here, we globally profiled the chromatin dynamics and transcriptional changes of developing human retinae, and revealed a unique spatiotemporal chromatin feature that accompanied human retinogenesis. Moreover, we also analyzed the retinal organoids (ROs), 3-dimential retinal structures derived from human induced pluripotent stem cells (hiPSCs), to evaluate the extent to which organoid systems recapitulate the human retinal development |
| Sample scope |
Monoisolate |
| Release date |
2019-05-01 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
|
XDA16020603
|
|
|
|
| Submitter |
wen
zhang (wen2017@mail.ustc.edu.cn)
|
| Organization |
University of Science and Technology of China |
| Submission date |
2018-10-16 |
