| 项目编号 |
PRJCA001040 |
| 项目标题 |
Pathogenesis of phytopathogenic bacteria |
| 涉及领域 |
Model organism |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Xanthomonas campestris pv. campestris
|
| 描述信息 |
we aimed to identifythe physiological substrates of Prc and investigate the role of Prc-catalysed proteolysis in controlling the environmental adaptation of X. campestris pv. campestris, which is more genetically amenable than X. oryzae pv. oryzae. Under osmostress, Prc directly bound and cleaved the sensor region of VgrS, a canonical histidine kinase (HK) controlling bacterial virulence and stress responses. Proteolysis of the VgrS sensor resulted in the inhibition of the autokinase activity of this HK, which caused a reprogramming of VgrS-triggered gene expressions and significantly promoted bacterial resistance to osmostress. Because Prc-like proteases and HKs are signaling proteins commonly distributed in the kingdom of Gram-negative bacteria, the inactivation of HK by periplasmic protease may be a general and important form of cross-talk between two-component signalling systems (TCSs) and proteolysis regulation. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2018-09-19 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
Grant Nos 31671989
|
|
| Chinese Academy of Sciences (CAS)
|
|
Grant No XDB11040700
|
|
| National Natural Science Foundation of China (NSFC)
|
|
Grant Nos 31600062
|
|
| National Natural Science Foundation of China (NSFC)
|
|
Grant Nos 31370127
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
Grant No 2011CB100700
|
|
|
|
| 提交者 |
Huan
Zhang (zhhuan@im.ac.cn)
|
| 提交单位 |
Beijing Institute of Microbiology of Chinese Academy of Sciences |
| 提交日期 |
2018-09-19 |
