Accession |
PRJCA000860 |
Title |
Genome-wide parent-of-origin DNA methylation analysis [Methyl-seq] |
Relevance |
Medical |
Data types |
Epigenomics
|
Organisms |
Homo sapiens
|
Description |
Genomic imprinting is a form of epigenetic regulation that results in expression of either the maternally or paternally inherited allele of a subset of genes. Imprinted loci contain differentially methylated regions (DMRs) where cytosine methylation marks one of the parental alleles, providing cis-acting regulatory elements that influence the allelic expression of surrounding genes, however to date the total number of imprinted loci within the human genome is unknown. To characterize known imprinted DMRS and identify novel imprinted loci we have performed whole-genome bisulphite sequencing and high-resolution DNA methylation array analysis of healthy tissues. Overall design: Sequencing of bisulfite converted DNA analysis of normal brain (white matter), liver and term placenta tissue. |
Sample scope |
Multiisolate |
Release date |
2018-05-30 |
Publication |
PubMed ID |
Article title |
Journal name |
DOI |
Year |
24402520
|
|
|
|
|
|
Accessions in other database |
Accession |
Database name |
PRJNA201856
|
NCBI
|
|
Submitter |
Fang
Liang (liangf@big.ac.cn)
|
Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences |
Submission date |
2018-04-28 |