| Accession |
PRJCA000628 |
| Title |
Time-series RNA-seq of tamoxifen resistant MCF7 cell line |
| Relevance |
Medical |
| Data types |
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Seventy percent of breast cancer are categorized as estrogen receptor (ER)-dependent tumor (luminal A-type) and initially respond to endocrine therapy using such as tamoxifen. However, about 30-40 % of tamoxifen-responsive tumor eventually acquires endocrine resistance after long-term treatment of this drug within 15 years after initial diagnosis. Due to this reason, molecular mechanisms of tamoxifen resistance have been intensively studied both in vivo and in vitro. As a result, a number of mechanisms have been proposed as a basis of tamoxifen resistance development. Detection of phase shift in time-course in response to tamoxifen treatment and identification of the genes responsible for the shift will be reasonable strategy to understand the drug resistance mechanisms. In order to detect the tamoxifen resistanct mechanisms of MCF7 cell line, we performed Poly A+ RNA-Seq on both tamoxifen treated and non-treated MCF7 cell line. |
| Sample scope |
Monoisolate |
| Release date |
2017-11-07 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 30383247
|
Hunt for the tipping point during endocrine resistance process in breast cancer by dynamic network biomarkers
|
Journal of Molecular Cell Biology
|
10.1093/jmcb/mjy059
|
2018
|
|
|
| Submitter |
Rui
Liu (scliurui@scut.edu.cn)
|
| Organization |
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
| Submission date |
2017-11-07 |
