Accession PRJCA000108
Title Genes underlying hypoxia adaptation of Tibetan domestic mammals and their functional roles in tumorigenesis
Relevance Agricultural
Umbrella project

eGPS: evolutionary Genotype-Phenotype Systems biology

Plateau Adaptability

Analysis of adaptive traits of domestic animals in the Qinghai Tibet Plateau

Data types Whole genome sequencing
Organisms
Description Hypoxia naturally occurs at high-altitudes and commonly within pathological conditions (e.g. tumors). Here, we used large-scale population genomes from horse, sheep, goat, cattle, pig and dog to investigate genetic mechanisms underlying hypoxia adaptation of mammals in short-term evolution. EPAS1, rarely documented in long-term adapted mammals, evolved convergently under positive selection in all of these domestic mammals. In addition, C10orf67, whose depletion inhibits apoptosis in response to hypoxia, also shows signature of convergent evolution. Interestingly, many genes involved in tumorigenesis were found to adaptively evolve, and we uncovered a novel positively selected gene YTHDF1, which is highly expressed in tumors. It depletion inhibits whereas over-expression promotes lung cancerous cell proliferation, migration and xenograft tumor in vivo. Our data not only provides insights into physiological evolution, convergent evolution and the difference between short-term and long-term adaptive evolution, but also facilitates searches for novel genes and potential therapeutic targets in hypoxic tumors.
Sample scope Monoisolate
Release date 2019-02-16
Data provider
Data provider Data provider URL
Grants
Agency program Grant ID Grant title
Chinese Academy of Sciences (CAS) XDB13020600 Strategic Priority Research Program
Chinese Academy of Sciences (CAS) Strategic Priority Research Program of Chinese Academy of Sciences (CAS) XDB13000000
External link
External link Link description
Submitter Dong  Dong  Wu  (wudongdong@mail.kiz.ac.cn)
Organization Kunming Institute of Zoology, CAS
Submission date 2015-11-19

Project Data

Resource name Description