Accession |
PRJCA000104 |
Title |
Genes underlying hypoxia adaptation of Tibetan domestic mammals and their functional roles in tumorigenesis |
Relevance |
Agricultural |
Umbrella project |
eGPS: evolutionary Genotype-Phenotype Systems biology
Plateau Adaptability
Analysis of adaptive traits of domestic animals in the Qinghai Tibet Plateau
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Data types |
Whole genome sequencing
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Organisms |
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Description |
Hypoxia naturally occurs at high-altitudes and commonly within pathological conditions (e.g. tumors). Here, we used large-scale population genomes from horse, sheep, goat, cattle, pig and dog to investigate genetic mechanisms underlying hypoxia adaptation of mammals in short-term evolution. EPAS1, rarely documented in long-term adapted mammals, evolved convergently under positive selection in all of these domestic mammals. In addition, C10orf67, whose depletion inhibits apoptosis in response to hypoxia, also shows signature of convergent evolution. Interestingly, many genes involved in tumorigenesis were found to adaptively evolve, and we uncovered a novel positively selected gene YTHDF1, which is highly expressed in tumors. It depletion inhibits whereas over-expression promotes lung cancerous cell proliferation, migration and xenograft tumor in vivo. Our data not only provides insights into physiological evolution, convergent evolution and the difference between short-term and long-term adaptive evolution, but also facilitates searches for novel genes and potential therapeutic targets in hypoxic tumors. |
Sample scope |
Monoisolate |
Release date |
2019-02-16 |
Data provider |
Data provider |
Data provider URL |
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Grants |
Agency |
program |
Grant ID |
Grant title |
Chinese Academy of Sciences (CAS)
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XDB13020600
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Strategic Priority Research Program
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Chinese Academy of Sciences (CAS)
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Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
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XDB13000000
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External link |
External link |
Link description |
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Submitter |
Dong
Dong
Wu (wudongdong@mail.kiz.ac.cn)
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Organization |
Kunming Institute of Zoology, CAS |
Submission date |
2015-11-19 |