e.g. IL6;  SIRT6; 

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 Welcome to Aging Atlas

Proteomics

(Protein-protein Interaction)


The proteomics module focuses on datasets that reflect physical protein associations and helps to build protein-protein interaction networks.






 Welcome to Aging Atlas

Pharmacogenomics

(Geroprotective Compounds)


The pharmacogenomics module focuses on geroprotectors. Currently, the module has a list of hundreds of compounds and contains omics datasets from drug therapy analysis (both in vivo and in vitro), revealing changes in gene regulation and expression caused by the supplementation of specific lifespan/healthspan-extending drugs.







Welcome to Aging Atlas


Aging Atlas aims to compile large gene expression and regulation datasets created by a range of high-throughput omics technologies and serve as a valuable resource for a range of life science researchers. The current implementation includes five modules: transcriptomics, epigenomics, single-cell transcriptomics, proteomics, and pharmacogenomics. Aging Atlas provides user-friendly functionalities to explore age-related changes in gene expression and provides download services for raw multi-omics data from aging-related research.

Gene of the Month


Gene name: FOXO3

Description for this gene: A transcription factor of the Fox family, FOXO3, is crucial in development. It also appears to regulate apoptotic signals in conjunction with FAS and AKT1. A homologue of FOXO3, daf-16, has been associated with ageing in roundworms, and overexpression of another homologue, dFOXO, in adult fat body of fruit flies increased longevity in females. Female mice without FOXO3 showed an ovarian phenotype of follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility. Two studies of genetic variation within FOXO3, have found it to be associated with exceptional human longevity, among people of Japanese and German origin. The G allele of FOXO3 single nucleotide polymorphism (SNP) rs2802292 has been associated with longevity in multiple populations. G-allele carriers among combined Japanese, white and black populations have a risk reduction of 10% for total mortality. [provided by GenAge]

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  Latest Updates

  • Aging-related gene set version 2.0 officially launched. (2021-01-13)

  • Eight data sets have been added in the transcriptomics module. (2021-01-05)

  • Two publications have been added in the single-cell transcriptomics module. (2020-10-17)

  • Nine publications have been added in the transcriptomics module. (2020-09-25)

  • The Aging Atlas version 1 was released. (2020-06-28)

  How to Cite

Aging Atlas Consortium, Aging Atlas: a multi-omics database for aging biology, Nucleic Acids Research, gkaa894,https://doi.org/10.1093/nar/gkaa894

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