The detail information of Histiocytosis, malignant
OMIA Basic Information

Possible human homologues (MIM numbers): -

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Year key mutation first reported: 2017

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB34 Bernese Mountain Dog 63.5-71.1 cm (male), 58.4-66 cm (female) 39-49.9 kg (male), 35.8-49.9 kg (female) Switzerland
CB105 Flat-Coated Retriever 58.4-62.2 cm (male), 55.9-59.7 cm (female) 27.2-31.8 kg United Kingdom
CB116 Golden Retriever 58.4-61 cm (male), 54.6-57.2 cm (female) 29.5-34 kg (male), 24.9-29.5 kg (female) United Kingdom (Scotland)
CB205 Rottweiler 61-68.6 cm (male), 55.9-63.5 cm (female) 49.9-59 kg (male), 34.9-49.9 kg (female) Germany
Associated Gene
Symbol Description Species Position Other Links
TP53 tumor protein p53 Canis lupus familiaris Chr5 : 32678721 - 32665395 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Evans,J.M.,Parker,H.G.,Rutteman,G.R.,Plassais,J.,Grinwis,G.C.M.,Harris,A.C.,Lana,S.E.,Ostrander,E.A.: :
Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds. PLoS Genet 17:e1009543, 2021.
Pubmed reference: 33983928 . DOI: 10.1371/journal.pgen.1009543 .
2019 Asada,H.,Tomiyasu,H.,Okada,K.,Chambers,J.K.,Goto-Koshino,Y.,Uchida,K.,Kagawa,Y.,Ohno,K.,Tsujimoto,H.: :
Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma. Res Vet Sci 124:57-60, 2019.
Pubmed reference: 30852355 . DOI: 10.1016/j.rvsc.2019.03.003 .
2019 Kennedy,K.,Thomas,R.,Durrant,J.,Jiang,T.,Motsinger-Reif,A.,Breen,M.: :
Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. Chromosome Res :, 2019.
Pubmed reference: 31011867 . DOI: 10.1007/s10577-019-09606-0 .
2017 Asada,H.,Tsuboi,M.,Chambers,J.K.,Uchida,K.,Tomiyasu,H.,Goto-Koshino,Y.,Ohno,K.,Tsujimoto,H.: :
A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma. J Vet Med Sci :, 2017.
Pubmed reference: 28867679 . DOI: 10.1292/jvms.17-0197 .
2015 Heinrich,F.,Contioso,V.B.,Stein,V.M.,Carlson,R.,Tipold,A.,Ulrich,R.,Puff,C.,Baumgärtner,W.,Spitzbarth,I.: :
Passage-dependent morphological and phenotypical changes of a canine histiocytic sarcoma cell line (DH82 cells). Vet Immunol Immunopathol 163:86-92, 2015.
Pubmed reference: 25534080 . DOI: 10.1016/j.vetimm.2014.11.006 .
2015 Mariani,C.L.,Jennings,M.K.,Olby,N.J.,Borst,L.B.,Brown,J.C.,Robertson,I.D.,Seiler,G.S.,MacKillop,E.: :
Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). J Vet Intern Med 29:607-13, 2015.
Pubmed reference: 25711602 . DOI: 10.1111/jvim.12554 .
2014 Barrett,L.E.,Pollard,R.E.,Zwingenberger,A.,Zierenberg-Ripoll,A.,Skorupski,K.A.: :
Radiographic characterization of primary lung tumors in 74 dogs. Vet Radiol Ultrasound 55:480-7, 2014.
Pubmed reference: 24674604 . DOI: 10.1111/vru.12154 .
2014 Boerkamp,K.M.,vanSteenbeek,F.G.,Penning,L.C.,GrootKoerkamp,M.J.,vanLeenen,D.,Vos-Loohuis,M.,Grinwis,G.C.,Rutteman,G.R.: :
The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression. PLoS One 9:e98258, 2014.
Pubmed reference: 24886914 . DOI: 10.1371/journal.pone.0098258 .
2014 Chikazawa,S.,Kitahara,Y.,Ando,E.,Hori,Y.,Hoshi,F.,Kanai,K.,Ito,N.,Higuchi,S.: :
Erythrophagocytosis enhances heme-dependent cytotoxicity of antimalarial drugs in canine histiocytic sarcoma cell line DH82. J Vet Med Sci 76:249-53, 2014.
Pubmed reference: 24065080 .
2014 Davis,B.W.,Ostrander,E.A.: :
Domestic dogs and cancer research: a breed-based genomics approach. ILAR J 55:59-68, 2014.
Pubmed reference: 24936030 . DOI: 10.1093/ilar/ilu017 .
2014 Denstedt,E.: :
Suspected disseminated histiocytic sarcoma in a 3-year-old Perro de Presa Canario dog. Can Vet J 55:181-4, 2014.
Pubmed reference: 24489399 .
2014 Empl,M.T.,Macke,S.,Winterhalter,P.,Puff,C.,Lapp,S.,Stoica,G.,Baumgärtner,W.,Steinberg,P.: :
The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin. Vet Comp Oncol 12:149-59, 2014.
Pubmed reference: 22882564 . DOI: 10.1111/j.1476-5829.2012.00349.x .
2014 Moore,P.F.: :
A review of histiocytic diseases of dogs and cats. Vet Pathol 51:167-84, 2014.
Pubmed reference: 24395976 . DOI: 10.1177/0300985813510413 .
2014 Takahashi,M.,Tomiyasu,H.,Hotta,E.,Asada,H.,Fukushima,K.,Kanemoto,H.,Fujino,Y.,Ohno,K.,Uchida,K.,Nakayama,H.,Tsujimoto,H.: :
Clinical characteristics and prognostic factors in dogs with histiocytic sarcomas in Japan. J Vet Med Sci 76:661-6, 2014.
Pubmed reference: 24441652 .
2014 VanderHart,D.J.,Reese,D.J.,Greenberg,S.M.: :
What is your diagnosis? Histiocytic sarcoma. J Am Vet Med Assoc 244:899-901, 2014.
Pubmed reference: 24697763 . DOI: 10.2460/javma.244.8.899 .
2013 Boerkamp,K.M.,vanderKooij,M.,vanSteenbeek,F.G.,vanWolferen,M.E.,GrootKoerkamp,M.J.,vanLeenen,D.,Grinwis,G.C.,Penning,L.C.,Wiemer,E.A.,Rutteman,G.R.: :
Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog. PLoS One 8:e71094, 2013.
Pubmed reference: 23936488 . DOI: 10.1371/journal.pone.0071094 .
2013 Dobson,J.M.: :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013.
Pubmed reference: 23738139 . DOI: 10.1155/2013/941275 .
2013 Erich,S.A.,Rutteman,G.R.,Teske,E.: :
Causes of death and the impact of histiocytic sarcoma on the life expectancy of the Dutch population of Bernese mountain dogs and Flat-coated retrievers. Vet J 198:678-83, 2013.
Pubmed reference: 24231621 . DOI: 10.1016/j.tvjl.2013.09.062 .
2013 Ito,K.,Kuroki,S.,Kobayashi,M.,Ono,K.,Washizu,T.,Bonkobara,M.: :
Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells. Vet J 196:536-40, 2013.
Pubmed reference: 23369384 . DOI: 10.1016/j.tvjl.2012.12.016 .
2013 NikolicNielsen,L.,Kjelgaard-Hansen,M.,Kristensen,A.T.: :
Monocyte chemotactic protein-1 and other inflammatory parameters in Bernese Mountain dogs with disseminated histiocytic sarcoma. Vet J 198:424-8, 2013.
Pubmed reference: 23992872 . DOI: 10.1016/j.tvjl.2013.07.030 .
2013 Silva,G.,Fachin,A.L.,Beleboni,R.O.,França,S.C.,Marins,M.: :
In vitro action of flavonoids in the canine malignant histiocytic cell line DH82. Molecules 18:15448-63, 2013.
Pubmed reference: 24352006 . DOI: 10.3390/molecules181215448 .
2013 Thakkar,P.,Pease,A.P.,Guiot,L.P.,Fitzgerald,S.D.,AduAddai,B.,Smedley,R.C.: :
What is your diagnosis? Disseminated histiocytic sarcoma. J Am Vet Med Assoc 243:1255-7, 2013.
Pubmed reference: 24134574 . DOI: 10.2460/javma.243.9.1255 .
2013 Yamazaki,H.,Takagi,S.,Hoshino,Y.,Hosoya,K.,Okumura,M.: :
Inhibition of survivin influences the biological activities of canine histiocytic sarcoma cell lines. PLoS One 8:e79810, 2013.
Pubmed reference: 24260303 . DOI: 10.1371/journal.pone.0079810 .
2013 Yamazaki,H.,Takagi,S.,Oh,N.,Hoshino,Y.,Hosoya,K.,Okumura,M.: :
Comparative analysis of mRNA expression of surface antigens between histiocytic and nonhistiocytic sarcoma in dogs. J Vet Intern Med 28:204-10, 2013.
Pubmed reference: 24428323 . DOI: 10.1111/jvim.12244 .
2013 vanKuijk,L.,vanGinkel,K.,deVos,J.P.,Brearley,M.J.,Butinar,J.,Gielen,I.,vanGarderen,E.,Chiers,K.,Verhoeven,P.S.: :
Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs. J Vet Intern Med 27:293-9, 2013.
Pubmed reference: 23458888 . DOI: 10.1111/jvim.12059 .
2012 Arnold,E.J.,Pressler,B.M.,Heng,H.G.: :
What is your diagnosis? Histiocytic sarcoma. J Am Vet Med Assoc 240:821-3, 2012.
Pubmed reference: 22443434 . DOI: 10.2460/javma.240.7.821 .
2012 Hafeman,S.D.,Varland,D.,Dow,S.W.: :
Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Vet Comp Oncol 10:44-56, 2012.
Pubmed reference: 22236140 . DOI: 10.1111/j.1476-5829.2011.00274.x .
2012 Mastrorilli,C.,Spangler,E.A.,Christopherson,P.W.,Aubry,O.A.,Newton,J.C.,Smith,A.N.,Kennis,R.A.,Weismann,J.L.,Moore,P.F.: :
Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping. Vet Clin Pathol 41:412-8, 2012.
Pubmed reference: 22747712 . DOI: 10.1111/j.1939-165X.2012.00449.x .
2012 Nielsen,L.N.,McEvoy,F.,Jessen,L.R.,Kristensen,A.T.: :
Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs. Vet Comp Oncol 10:124-34, 2012.
Pubmed reference: 22235831 . DOI: 10.1111/j.1476-5829.2011.00285.x .
2012 Sapierzyński,R.,Jagielski,D.,Dolka,I.,Fabisiak,M.: :
Cytopathological diagnosis of visceral histiocytic sarcoma in five dogs. Pol J Vet Sci 15:751-8, 2012.
Pubmed reference: 23390766 .
2012 Shearin,A.L.,Hedan,B.,Cadieu,E.,Erich,S.A.,Schmidt,E.V.,Faden,D.L.,Cullen,J.,Abadie,J.,Kwon,E.M.,Gröne,A.,Devauchelle,P.,Rimbault,M.,Karyadi,D.M.,Lynch,M.,Galibert,F.,Breen,M.,Rutteman,G.R.,André,C.,Parker,H.G.,Ostrander,E.A.: :
The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer Epidemiol Biomarkers Prev 21:1019-27, 2012.
Pubmed reference: 22623710 . DOI: 10.1158/1055-9965.EPI-12-0190-T .
2012 Tsai,P.C.,Breen,M.: :
Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs. Am J Vet Res 73:1335-43, 2012.
Pubmed reference: 22924713 . DOI: 10.2460/ajvr.73.9.1335 .
2012 Tsai,S.,Sutherland-Smith,J.,Burgess,K.,Ruthazer,R.,Sato,A.: :
Imaging characteristics of intrathoracic histiocytic sarcoma in dogs. Vet Radiol Ultrasound 53:21-7, 2012.
Pubmed reference: 21831241 . DOI: 10.1111/j.1740-8261.2011.01863.x .
2011 Constantino-Casas,F.,Mayhew,D.,Hoather,T.M.,Dobson,J.M.: :
The clinical presentation and histopathologic-immunohistochemical classification of histiocytic sarcomas in the Flat Coated Retriever. Vet Pathol 48:764-71, 2011.
Pubmed reference: 20930108 . DOI: 10.1177/0300985810385153 .
2011 Hedan,B.,Thomas,R.,Motsinger-Reif,A.,Abadie,J.,Andre,C.,Cullen,J.,Breen,M.: :
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer 11:201, 2011.
Pubmed reference: 21615919 . DOI: 10.1186/1471-2407-11-201 .
2011 Klahn,S.L.,Kitchell,B.E.,Dervisis,N.G.: :
Evaluation and comparison of outcomes in dogs with periarticular and nonperiarticular histiocytic sarcoma. J Am Vet Med Assoc 239:90-6, 2011.
Pubmed reference: 21718201 . DOI: 10.2460/javma.239.1.90 .
2011 Soare,T.,Noble,P.J.,Hetzel,U.,Fonfara,S.,Kipar,A.: :
Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. J Comp Pathol 146:168-74, 2011.
Pubmed reference: 21741052 . DOI: 10.1016/j.jcpa.2011.05.006 .
2011 Sterenczak,K.A.,Kleinschmidt,S.,Wefstaedt,P.,Eberle,N.,Hewicker-Trautwein,M.,Bullerdiek,J.,Nolte,I.,MuruaEscobar,H.: :
Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis). Anticancer Res 31:1541-8, 2011.
Pubmed reference: 21617208 .
2010 André,C.,Abadie,J.,Hedan,B.,deBrito,C.,Lagadic,M.,Poujade,A.,Devauchelle,P.: :
Proliférations histiocytaires canines. D’après une étude épidémiologique, clinique et génétique de 100 cas de sarcome histiocytaire chez le Bouvier bernois. [Canine histiocytic proliferations. From an epidemiological, clinical, and genetic study of 100 histiocytic sarcomas in the Bernese mountain dog breed] Pratique médicale et chirurgicale de l’animal de compagnie (PMAC) 45:9-17, 2010.
2010 Castellanos,V.C.,O'Neill,S.,Seiler,G.S.: :
What is your diagnosis? Histiocytic sarcoma. J Am Vet Med Assoc 236:1293-4, 2010.
Pubmed reference: 20550442 . DOI: 10.2460/javma.236.12.1293 .
2010 Friedrichs,K.R.,Thomas,C.,Plier,M.,Andrews,G.A.,Chavey,P.S.,Young,K.M.: :
Evaluation of serum ferritin as a tumor marker for canine histiocytic sarcoma. J Vet Intern Med 24:904-11, 2010.
Pubmed reference: 20561186 . DOI: 10.1111/j.1939-1676.2010.0543.x .
2010 Hafeman,S.,London,C.,Elmslie,R.,Dow,S.: :
Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs. Cancer Immunol Immunother 59:441-52, 2010.
Pubmed reference: 19760220 . DOI: 10.1007/s00262-009-0763-y .
2010 Nielsen,L.,Andreasen,SN.,Andersen,SD.,Kristensen,AT.: :
Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. Vet Rec 166:199-202, 2010.
Pubmed reference: 20154310 . DOI: 10.1136/vr.b4756 .
2010 Rassnick,K.M.,Moore,A.S.,Russell,D.S.,Northrup,N.C.,Kristal,O.,Bailey,D.B.,Flory,A.B.,Kiselow,M.A.,Intile,J.L.: :
Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. J Vet Intern Med 24:1528-31, 2010.
Pubmed reference: 21155191 .
2009 Abadie,J.,Hédan,B.,Cadieu,E.,DeBrito,C.,Devauchelle,P.,Bourgain,C.,Parker,H.G.,Vaysse,A.,Margaritte-Jeannin,P.,Galibert,F.,Ostrander,E.A.,André,C.: :
Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed. J Hered 100 Suppl 1:S19-27, 2009.
Pubmed reference: 19531730 . DOI: 10.1093/jhered/esp039 .
2009 Maruo,T.,Namikawa,K.,Kunihiro,A.,Lynch,J.,Shida,T.,Kishikawa,S.: :
Large granular lymphocytic leukaemia complicated with histiocytic sarcoma in a dog. J S Afr Vet Assoc 80:261-3, 2009.
Pubmed reference: 20458870 .
2009 Wagter,H.W.,Vos,A.J.,vandenIngh,T.: :
[A localised histocytic sarcoma in the stomach of a dog]. Tijdschr Diergeneeskd 134:526-8, 2009.
Pubmed reference: 19579381 .
2008 Coleman,K.D.,Lurie,D.M.,Blaik,M.A.,Demuth,G.,Kirkby,K.: :
What is your diagnosis? Histiocytic sarcoma. J Am Vet Med Assoc 232:1801-2, 2008.
Pubmed reference: 18598147 . DOI: 10.2460/javma.232.12.1801 .
2007 Fulmer,A.K.,Mauldin,G.E.: :
Canine histiocytic neoplasia: an overview. Can Vet J 48:1041-3, 1046-50, 2007.
Pubmed reference: 17987966 .
2007 Schultz,R.M.,Puchalski,S.M.,Kent,M.,Moore,P.F.: :
Skeletal lesions of histiocytic sarcoma in nineteen dogs. Vet Radiol Ultrasound 48:539-43, 2007.
Pubmed reference: 18018725 .
2006 Dobson,J.,Villiers,E.,Roulois,A.,Gould,S.,Mellor,P.,Hoather,T.,Watson,P.: :
Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia. Vet Rec 158:825-9, 2006.
Pubmed reference: 16782856 .
2006 Soller,J.T.,MuruaEscobar,H.,Janssen,M.,Fork,M.,Bullerdiek,J.,Nolte,I.: :
Cytokine genes single nucleotide polymorphism (SNP) screening analyses in canine malignant histiocytosis. Anticancer Res 26:3417-20, 2006.
Pubmed reference: 17094461 .
2006 Thio,T.,Hilbe,M.,Grest,P.,Pospischil,A.: :
Malignant histiocytosis of the brain in three dogs. J Comp Pathol 134:241-4, 2006.
Pubmed reference: 16537081 . DOI: 10.1016/j.jcpa.2005.09.005 .
2006 Voegeli,E.,Welle,M.,Hauser,B.,Dolf,G.,Flückiger,M.: :
[Histiocytic sarcoma in the Swiss population of Bernese mountain dogs: a retrospective study of its genetic predisposition]. Schweiz Arch Tierheilkd 148:281-8, 2006.
Pubmed reference: 16826705 . DOI: 10.1024/0036-7281.148.6.281 .
2006 Zavodovskaya,R.,Liao,AT.,Jones,CL.,Yip,B.,Chien,MB.,Moore,PF.,London,CA.: :
Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs. Am J Vet Res 67:633-41, 2006.
Pubmed reference: 16579756 . DOI: 10.2460/ajvr.67.4.633 .
1996 Ramsey,I.K.,Mckay,J.S.,Rudorf,H.,Dobson,J.M.: :
Malignant histiocytosis in three Bernese Mountain dogs Veterinary Record 138:440-444, 1996.
Pubmed reference: 8735262 .
1995 Padgett,G.A.,Madewell,B.R.,Keller,E.T.,Todar,L.,Packard,M.: :
Inheritance of histiocytosis in Bernese mountain dogs Journal of Small Animal Practice 36:93-98, 1995.
Pubmed reference: 7783441 .
1995 Paterson,S.,Boydell,P.,Pike,R.: :
Systemic histiocytosis in the Bernese mountain dog Journal of Small Animal Practice 36:233-236, 1995.
Pubmed reference: 7650919 .
1993 Hayden,D.W.,Waters,D.J.,Burke,B.A.,Manivel,J.C.: :
Disseminated Malignant Histiocytosis in a Golden Retriever - Clinicopathologic, Ultrastructural, and Immunohistochemical Findings Veterinary Pathology 30:256-264, 1993.
Pubmed reference: 8333107 .