The detail information of Acrodermatitis, lethal
OMIA Basic Information
Possible human homologues (MIM numbers): -
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal Recessive
Considered a defect: yes
Year key mutation first reported: 2018
Species-specific name: Lethal acrodermatitis
Species-specific symbol: LAD
More detail information can see in
Associated Breeds
There are associated breeds.
Associated Gene
Symbol | Description | Species | Position | Other Links |
---|---|---|---|---|
MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | Canis lupus familiaris | Chr14 : 5699541 - 5374406 | Homologene, Ensembl, NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2018 |
Bauer,A.,Jagannathan,V.,Högler,S.,Richter,B.,McEwan,N.A.,Thomas,A.,Cadieu,E.,André,C.,Hytönen,M.K.,Lohi,H.,Welle,M.M.,Roosje,P.,Mellersh,C.,Casal,M.L.,Leeb,T.: :
MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS Genet 14:e1007264, 2018. Pubmed reference: 29565995 . DOI: 10.1371/journal.pgen.1007264 . |
2007 |
Grider,A.,Mouat,M.F.,Mauldin,E.A.,Casal,M.L.: :
Analysis of the liver soluble proteome from bull terriers affected with inherited lethal acrodermatitis. Mol Genet Metab 92:249-57, 2007. Pubmed reference: 17693109 . DOI: 10.1016/j.ymgme.2007.07.003 . |
2003 |
McEwan,N.A.,Huang,H.P.,Mellor,D.J.: :
Immunoglobulin levels in Bull terriers suffering from lethal acrodermatitis. Vet Immunol Immunopathol 96:235-8, 2003. Pubmed reference: 14592736 . |
2001 |
McEwan,N.A.: :
Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract 42:291-7, 2001. Pubmed reference: 11440398 . |
2000 |
McEwan,N.A.,McNeil,P.E.,Thompson,H.,McCandlish,I.A.: :
Diagnostic features, confirmation and disease progression in 28 cases of lethal acrodermatitis of bull terriers. J Small Anim Pract 41:501-7, 2000. Pubmed reference: 11105789 . |
1999 |
Colombini,S.: :
Canine zinc-responsive dermatosis. Vet Clin North Am Small Anim Pract 29:1373-83, 1999. Pubmed reference: 10563006 . |
1997 |
Uchida,Y.,Moon-Fanelli,A.A.,Dodman,N.H.,Clegg,M.S.,Keen,C.L.: :
Serum concentrations of zinc and copper in bull terriers with lethal acrodermatitis and tail-chasing behavior. Am J Vet Res 58:808-10, 1997. Pubmed reference: 9256960 . |
1996 |
Patel,A.: :
What is your diagnosis? Lethal acrodermatitis of English bull terriers. J Small Anim Pract 37:567, 600, 1996. Pubmed reference: 8981276 . |
1990 |
McEwan,N.A.: :
Lethal Acrodermatitis of Bull Terriers Veterinary Record 127:95, 1990. Pubmed reference: 2402865 . |
1986 |
Jezyk,P.F.,Haskins,M.E.,MacKay-Smith,W.E.,Patterson,D.F.: :
Lethal acrodermatitis in bull terriers. J Am Vet Med Assoc 188:833-9, 1986. Pubmed reference: 3710872 . |