The detail information of Acrodermatitis, lethal
OMIA Basic Information

Possible human homologues (MIM numbers): -

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2018

Species-specific name: Lethal acrodermatitis

Species-specific symbol: LAD

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
Symbol Description Species Position Other Links
MKLN1 muskelin 1, intracellular mediator containing kelch motifs Canis lupus familiaris Chr14 : 5699541 - 5374406 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2018 Bauer,A.,Jagannathan,V.,Högler,S.,Richter,B.,McEwan,N.A.,Thomas,A.,Cadieu,E.,André,C.,Hytönen,M.K.,Lohi,H.,Welle,M.M.,Roosje,P.,Mellersh,C.,Casal,M.L.,Leeb,T.: :
MKLN1 splicing defect in dogs with lethal acrodermatitis. PLoS Genet 14:e1007264, 2018.
Pubmed reference: 29565995 . DOI: 10.1371/journal.pgen.1007264 .
2007 Grider,A.,Mouat,M.F.,Mauldin,E.A.,Casal,M.L.: :
Analysis of the liver soluble proteome from bull terriers affected with inherited lethal acrodermatitis. Mol Genet Metab 92:249-57, 2007.
Pubmed reference: 17693109 . DOI: 10.1016/j.ymgme.2007.07.003 .
2003 McEwan,N.A.,Huang,H.P.,Mellor,D.J.: :
Immunoglobulin levels in Bull terriers suffering from lethal acrodermatitis. Vet Immunol Immunopathol 96:235-8, 2003.
Pubmed reference: 14592736 .
2001 McEwan,N.A.: :
Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract 42:291-7, 2001.
Pubmed reference: 11440398 .
2000 McEwan,N.A.,McNeil,P.E.,Thompson,H.,McCandlish,I.A.: :
Diagnostic features, confirmation and disease progression in 28 cases of lethal acrodermatitis of bull terriers. J Small Anim Pract 41:501-7, 2000.
Pubmed reference: 11105789 .
1999 Colombini,S.: :
Canine zinc-responsive dermatosis. Vet Clin North Am Small Anim Pract 29:1373-83, 1999.
Pubmed reference: 10563006 .
1997 Uchida,Y.,Moon-Fanelli,A.A.,Dodman,N.H.,Clegg,M.S.,Keen,C.L.: :
Serum concentrations of zinc and copper in bull terriers with lethal acrodermatitis and tail-chasing behavior. Am J Vet Res 58:808-10, 1997.
Pubmed reference: 9256960 .
1996 Patel,A.: :
What is your diagnosis? Lethal acrodermatitis of English bull terriers. J Small Anim Pract 37:567, 600, 1996.
Pubmed reference: 8981276 .
1990 McEwan,N.A.: :
Lethal Acrodermatitis of Bull Terriers Veterinary Record 127:95, 1990.
Pubmed reference: 2402865 .
1986 Jezyk,P.F.,Haskins,M.E.,MacKay-Smith,W.E.,Patterson,D.F.: :
Lethal acrodermatitis in bull terriers. J Am Vet Med Assoc 188:833-9, 1986.
Pubmed reference: 3710872 .