The detail information of Cleft palate 1
OMIA Basic Information
Possible human homologues (MIM numbers):
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal Recessive
Considered a defect: yes
Year key mutation first reported: 2014
Species-specific name: -
Species-specific symbol: CP1
More detail information can see in
Associated Breeds
| iDog Breed Number | Breed Name | Personality | Height | Weight | History | Breed Source |
|---|---|---|---|---|---|---|
| CB173 | Nova Scotia Duck Tolling Retriever | 45.7-53.3 cm (male), 43.2-50.8 cm (female) | 15.9-22.7 kg | Canada |
Associated Gene
| Symbol | Description | Species | Position | Other Links |
|---|---|---|---|---|
| DLX6 | distal-less homeobox 6 | Canis lupus familiaris | Chr14 : 21882338 - 21903013 | Homologene, Ensembl, NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2017 |
Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: :
Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 . |
| 2014 |
Wolf,Z.T.,Leslie,E.J.,Arzi,B.,Jayashankar,K.,Karmi,N.,Jia,Z.,Rowland,D.J.,Young,A.,Safra,N.,Sliskovic,S.,Murray,J.C.,Wade,C.M.,Bannasch,D.L.: :
A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence. PLoS Genet 10:e1004257, 2014. Pubmed reference: 24699068 . DOI: 10.1371/journal.pgen.1004257 . |