The detail information of Cleft lip with or without cleft palate
OMIA Basic Information
Possible human homologues (MIM numbers):
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal Recessive
Considered a defect: yes
Year key mutation first reported: 2015
Species-specific name: -
Species-specific symbol: CL/P
More detail information can see in
Associated Breeds
| iDog Breed Number | Breed Name | Personality | Height | Weight | History | Breed Source |
|---|---|---|---|---|---|---|
| CB173 | Nova Scotia Duck Tolling Retriever | 45.7-53.3 cm (male), 43.2-50.8 cm (female) | 15.9-22.7 kg | Canada |
Associated Gene
| Symbol | Description | Species | Position | Other Links |
|---|---|---|---|---|
| ADAMTS20 | ADAM metallopeptidase with thrombospondin type 1 motif, 20 | Canis lupus familiaris | Chr27 : 10688121 - 10851084 | Homologene, Ensembl, NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2019 |
Roman,N.,Carney,P.C.,Fiani,N.,Peralta,S.: :
Incidence patterns of orofacial clefts in purebred dogs. PLoS One 14:e0224574, 2019. Pubmed reference: 31682628 . DOI: 10.1371/journal.pone.0224574 . |
| 2017 |
Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: :
Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 . |
| 2015 |
Wolf,Z.T.,Brand,H.A.,Shaffer,J.R.,Leslie,E.J.,Arzi,B.,Willet,C.E.,Cox,T.C.,McHenry,T.,Narayan,N.,Feingold,E.,Wang,X.,Sliskovic,S.,Karmi,N.,Safra,N.,Sanchez,C.,Deleyiannis,F.W.,Murray,J.C.,Wade,C.M.,Marazita,M.L.,Bannasch,D.L.: :
Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLoS Genet 11:e1005059, 2015. Pubmed reference: 25798845 . DOI: 10.1371/journal.pgen.1005059 . |
| 2009 |
Kemp,C.,Thiele,H.,Dankof,A.,Schmidt,G.,Lauster,C.,Fernahl,G.,Lauster,R.: :
Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs. Cleft Palate Craniofac J 46:81-8, 2009. Pubmed reference: 19115787 . DOI: 10.1597/06-229.1 . |
| 1972 |
Edmonds,L.,Stewart,R.W.,Selby,L.: :
Cleft lip and palate in dogs (Boxer breed): a preliminary report Carnivore Genetics Newsletter 9:204-209, 1972. |
| 1961 |
Calnan,J.: :
The comparative anatomy of cleft lip and palate. I. Classification of cleft lip and palate in dogs. Br J Plast Surg 14:180-4, 1961. Pubmed reference: 13875838 . |