The detail information of Achondroplasia
Basic Information

Disease Description: Abnormal development of cartilage leading to dwarfism (seen aberrantly in most breeds, but that's what makes a Basset hound and other achondroplastic breeds long and low).

Inherit Mode: -

Disease Symptom: Offspring can look normal at birth and weaning, but at the age of 2.5 to 4 months the longitudinal growth of the spine and leg bones can retard in the dwarfs compared with the normal littermates. Most dwarfs perform well, even in the field. Canine achondroplasia can be a mild condition, with slightly bowing or simply short legs, causing no discomfort to the animal.

Disease Cause: -

Disease Diagnose: -

Treat Method: Severe achondroplasia requires extensive orthopedic surgery to both alleviate pain and allow the dog to function normally. This surgery, most frequently an ulna, or radius surgery, is generally performed at one year of age when bone growth is nearly complete. Surgical success is variable.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Achondroplasia - - - -
Chondrodysplasia - Autosomal -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB23 Bavarian Mountain Scent Hound Loyal, Versatile, Reserved with Strangers 17-20.5 inches 37-66 pound
CB121 Greater Swiss Mountain Dog Faithful, dependable, family oriented; Swissies are famously even-tempered 64.8-72.4 cm (male), 60.2-68.6 cm (female) 52.2-63.5 kg (male), 38.6-49.9 kg (female) Switzerland
CB215 Sealyham Terrier Alert and outgoing; stubbornness is tempered by a sly sense of humor 26.7 cm 10.4-10.9 kg (male), slightly less (females) United Kingdom (Wales)
CB217 Japanese Shiba Inu Alert, active, and attentive 35.6-43.2 cm (male), 33-40.6 cm (female) 8.2-10.9 kg (male), 6.8-9.1 kg (female) Japan
CB268 Miniature Poodle Intelligent, Eager-to-please , Charming companion 25-38 cm 4.5-6.8kg France&Germany
CB270 Toy Poodle Intelligent, eager to please, quick to learn and an affectionate, loyal pet. under 25 cm
References
2010 Bannasch,D.,Young,A.,Myers,J.,Truvé,K.,Dickinson,P.,Gregg,J.,Davis,R.,Bongcam-Rudloff,E.,Webster,M.T.,Lindblad-Toh,K.,Pedersen,N.: :
Localization of canine brachycephaly using an across breed mapping approach. PLoS One 5:e9632, 2010.
Pubmed reference: 20224736 . DOI: 10.1371/journal.pone.0009632 .
2009 Kaessmann,H.: :
Genetics. More than just a copy. Science 325:958-9, 2009.
Pubmed reference: 19696341 . DOI: 10.1126/science.1178487 .
2009 Parker,HG.,Vonholdt,BM.,Quignon,P.,Margulies,EH.,Shao,S.,Mosher,DS.,Spady,TC.,Elkahloun,A.,Cargill,M.,Jones,PG.,Maslen,CL.,Acland,GM.,Sutter,NB.,Kuroki,K.,Bustamante,CD.,Wayne,RK.,Ostrander,EA.: :
An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs. Science 325:995-8, 2009.
Pubmed reference: 19608863 . DOI: 10.1126/science.1173275 .
2008 Young,AE.,Bannasch,DL.: :
SNPS in the promoter regions of the canine RMRP and SHOX genes are not associated with canine chondrodysplasia. Anim Biotechnol 19:1-5, 2008.
Pubmed reference: 18228171 . DOI: 10.1080/10495390701638328 .
2005 Pollinger,J.P.,Bustamante,C.D.,Fledel-Alon,A.,Schmutz,S.,Gray,M.M.,Wayne,R.K.: :
Selective sweep mapping of genes with large phenotypic effects. Genome Res 15:1809-19, 2005.
Pubmed reference: 16339379 . DOI: 10.1101/gr.4374505 .
2000 Martinez,S.,Valdes,J.,Alonso,R.A.: :
Achondroplastic dog breeds have no mutations in the transmembrane domain of the FGFR-3 gene Canadian Journal of Veterinary Research - Revue Canadienne de Recherche Veterinaire 64:243-245, 2000.
Pubmed reference: 11041504 .
1994 Bingel,S.A.,Sande,R.D.: :
Chondrodysplasia in five Great Pyrenees Journal of the American Veterinary Medical Association 205:845-848, 1994.
Pubmed reference: 7829378 .
1975 Braund,K.G.,Ghosh,P.,Taylor,T.K.F.,Larsen,L.H.: :
Morphological studies of the canine intervertebral disc: the assignment of the Beagle to the achondroplastic classification Research in Veterinary Science 19:167-172, 1975.
Pubmed reference: 1166121 .
1952 Hansen,H.J.: :
A pathologic-anatomical study on disc degeneration in dog, with special reference to the so-called enchondrosis intervertebralis. Acta Orthop Scand Suppl 11:1-117, 1952.
Pubmed reference: 14923291 .
1951 Hansen,H.J.: :
A pathologic-anatomical interpretation of disc degeneration in dogs. Acta Orthop Scand 20:280-93, 1951.
Pubmed reference: 14894198 .