Disease Description: A disease of weakened heart muscles. Common in giant breeds, boxers, Doberman pinschers.
Inherit Mode: -
Disease Symptom: Dilated cardiomyopathy in dogs often does not display any symptoms, which is why it often leads to sudden tragedy. However, signs to watch out for include cold paws and legs, weakness and breathlessness with even mild exertion, and unusually pale mucus membranes.
Disease Cause: It is not clear why cardiomyopathy occurs, but it seems to be rather common among certain breeds. Dilated cardiomyopathy in Dobermans is quite a common problem. Cardiomyopathy in boxers is also quite common, and other large breeds such as Great Danes and St Bernards also seem to be susceptible.
Disease Diagnose: -
Treat Method: Dilated cardiomyopathy in dogs cannot be cured, and treatment typically aims to reduce the clinical symptoms and prolong the life of the dog as much as possible. A variety of medications are used for this purpose, and these must of course be continued throughout the dog's life. Some of the drugs improve the heart's ability to contract and function normally, others dilate blood vessels so that blood flow faces less resistance, and still others control arrhythmias.
Breeder Advice: -
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Cardiomyopathy | - | - | - | - | |
Cardiomyopathy, hypertrophic | - | - | - |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB49 | Boykin Spaniel | Friendly, eager, trainable, lovable | 39.4-45.7 cm (male), 35.6-41.9 cm (female) | 13.6-18.1 kg (male), 11.3-15.9 kg (female) | United States |
CB89 | Dogo Argentino | Loyal, trustworthy,courageous | 61-68.6 cm (male), 59.7-66 cm (female) | 36.3-45.4 kg | Argentina |
CB120 | Great Pyrenees | Calm, patient, smart; strong-willed yet affectionate | 68.6-81.3 cm (male), 63.5-73.7 cm (female) | 45.4 kg & up (male), 38.6 kg & up (female) | France, Spain |
CB135 | Italian Greyhound | Sensitive and alert, playful, highly affectionate | 33-38.1 cm | 3.2-6.4 kg | Italy |
CB167 | Norfolk Terrier | Alert, fearless, fun-loving, and more sociable than the usual terrier | 22.9-25.4 cm | 5-5.4 kg | United Kingdom |
CB237 | Swedish Lapphund | Playful, Intelligent, Lively | 16-20 inches | 30-45 pounds | Sweden |
2020 |
Gurtner,C.,Hug,P.,Kleiter,M.,Köhler,K.,Dietschi,E.,Jagannathan,V.,Leeb,T.: :
<i>YARS2</i> Missense Variant in Belgian Shepherd Dogs with Cardiomyopathy and Juvenile Mortality. Genes (Basel) 11:, 2020. Pubmed reference: 32183361 . DOI: 10.3390/genes11030313 . |
2019 |
Yost,O.,Friedenberg,S.G.,Jesty,S.A.,Olby,N.J.,Meurs,K.M.: :
The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model. Gene 697:118-122, 2019. Pubmed reference: 30794913 . DOI: 10.1016/j.gene.2019.02.022 . |
2013 |
Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 . |
2011 |
Palermo,V.,StaffordJohnson,MJ.,Sala,E.,Brambilla,PG.,Martin,MW.: :
Cardiomyopathy in Boxer dogs: A retrospective study of the clinical presentation, diagnostic findings and survival. J Vet Cardiol :, 2011. Pubmed reference: 21306968 . DOI: 10.1016/j.jvc.2010.06.005 . |
2004 |
Meurs,KM.: :
Boxer dog cardiomyopathy: an update. Vet Clin North Am Small Anim Pract 34:1235-44, viii, 2004. Pubmed reference: 15325480 . DOI: 10.1016/j.cvsm.2004.05.003 . |
2004 |
Tarducci,A.,Abate,O.,Borgarelli,M.,Borrelli,A.,Zanatta,R.,Cagnasso,A.: :
Serum values of cardiac troponin-T in normal and cardiomyopathic dogs. Vet Res Commun 28 Suppl 1:385-8, 2004. Pubmed reference: 15373003 . |
2003 |
Washizu,M.,Takemura,N.,Machida,N.,Nawa,H.,Yamamoto,T.,Mitake,H.,Washizu,T.: :
Hypertrophic cardiomyopathy in an aged dog Journal of Veterinary Medical Science 65:753-6, 2003. Pubmed reference: 12867741 . |
2002 |
Ahmet,I.,Sawa,Y.,Iwata,K.,Matsuda,H.: :
Gene transfection of hepatocyte growth factor attenuates cardiac remodeling in the canine heart: A novel gene therapy for cardiomyopathy Journal of Thoracic & Cardiovascular Surgery 124:957-963, 2002. |
2001 |
Sleeper,M.M.,Henthorn,P.S.,Lankford,E.B.: :
Differing opinion regarding the etiology of juvenile cardiomyopathy in Portuguese water dogs American Journal of Medical Genetics 104:262-263, 2001. Pubmed reference: 11754056 . |
2000 |
Argenziano,M.,Dickstein,M.L.: :
Cardiovascular effects of inhaled nitric oxide in a canine model of cardiomyopathy Annals of Thoracic Surgery 69:1644-1645, 2000. Pubmed reference: 10881876 . |
2000 |
Calvert,C.A.,Jacobs,G.J.,Smith,D.D.,Rathbun,S.L.,Pickus,C.W.: :
Association between results of ambulatory electrocardiography and development of cardiomyopathy during long-term follow-up of Doberman Pinschers Journal of the American Veterinary Medical Association 216:34-39, 2000. Pubmed reference: 10638315 . |
2000 |
Loh,E.: :
Cardiovascular effects of inhaled nitric oxide in a canine model of cardiomyopathy - Reply Annals of Thoracic Surgery 69:1645, 2000. Pubmed reference: 10881877 . |
2000 |
Mohr,A.J.,Kirberger,R.M.: :
Arrhythmogenic right ventricular cardiomyopathy in a dog Journal of the South African Veterinary Medical Association 71:125-130, 2000. |
2000 |
Vollmar,A.C.: :
The prevalence of cardiomyopathy in the Irish wolfhound: A clinical study of 500 dogs Journal of the American Animal Hospital Association 36:125-132, 2000. Pubmed reference: 10730622 . |
1998 |
Calvert,C.A.,Jacobs,G.J.,Kraus,M.: :
Possible ventricular late potentials in doberman pinschers with occult cardiomyopathy Journal of the American Veterinary Medical Association 213:235 ff., 1998. |
1998 |
Calvert,C.A.,Jacobs,G.J.,Medleau,L.,Pickus,C.W.,Brown,J.,Mcdermott,M.: :
Thyroid-stimulating hormone stimulation tests in cardiomyopathic doberman pinschers - a retrospective study Journal of Veterinary Internal Medicine 12:343-348, 1998. Pubmed reference: 9773410 . |
1998 |
Meurs,K.R.: :
Insights into the hereditability of canine cardiomyopathy Veterinary Clinics of North America - Small Animal Practice 28:1449-+, 1998. |
1997 |
Calvert,C.A.,Hall,G.,Jacobs,G.,Pickus,C.: :
Clinical and pathologic findings in Doberman Pinschers with occult cardiomyopathy that died suddenly or developed congestive heart failure - 54 cases (1984-1991) Journal of the American Veterinary Medical Association 210:505 ff., 1997. |
1997 |
Calvert,C.A.,Pickus,C.W.,Jacobs,G.J.,Brown,J.: :
Signalment, survival, and prognostic factors in doberman pinschers with end-stage cardiomyopathy Journal of Veterinary Internal Medicine 11:323-326, 1997. Pubmed reference: 9470155 . |
1996 |
Calvert,C.A.,Jacobs,G.J.,Pickus,C.W.: :
Unfavorable influence of anesthesia and surgery on Doberman Pinschers with occult cardiomyopathy Journal of the American Animal Hospital Association 32:57-62, 1996. Pubmed reference: 8963737 . |
1996 |
Calvert,C.A.,Jacobs,G.J.,Pickus,C.W.: :
Bradycardia-associated episodic weakness, syncope, and aborted sudden death in cardiomyopathic Doberman Pinschers Journal of Veterinary Internal Medicine 10:88-93, 1996. Pubmed reference: 8683487 . |
1996 |
Calvert,C.A.,Pickus,C.W.,Jacobs,G.J.: :
Efficacy and toxicity of tocainide for the treatment of ventricular tachyarrhythmias in Doberman Pinschers with occult cardiomyopathy Journal of Veterinary Internal Medicine 10:235-240, 1996. Pubmed reference: 8819048 . |
1996 |
Jacobs,G.J.: :
Secondary canine cardiomyopathies - their causes and characteristics Veterinary Medicine 91:534 ff., 1996. |
1996 |
Jacobs,G.J.: :
Treating cardiomyopathy in dogs and cats Veterinary Medicine 91:544 ff., 1996. |
1996 |
Jacobs,G.J.: :
Reviewing the various types of primary cardiomyopathy in dogs Veterinary Medicine 91:524 ff., 1996. |
1996 |
Ewers,R.: :
What is your diagnosis - hypertrophic cardiomyopathy (hcm) with secondary thromboembolic disease Journal of Small Animal Practice 37:295 ff., 1996. |
1995 |
Mcentee,K.,Clercx,C.,Snaps,F.,Henroteaux,M.: :
Clinical, Electrocardiographic, and Echocardiographic Improvements After L-Carnitine Supplementation in a Cardiomyopathic Labrador Canine Practice 20:12-15, 1995. |
1995 |
O'Brien,P.J.,Duke,A.L.,Shen,H.,Shohet,R.V.: :
Myocardial mRNA content and stability, and enzyme activities of Ca-cycling and aerobic metabolism in canine dilated cardiomyopathies Molecular and Cellular Biochemistry 142:139-150, 1995. Pubmed reference: 7770066 . |
1993 |
Liu,S.K.,Roberts,W.C.,Maron,B.J.: :
Comparison of Morphologic Findings in Spontaneously Occurring Hypertrophic Cardiomyopathy in Humans, Cats and Dogs American Journal of Cardiology 72:944-951, 1993. Pubmed reference: 8213553 . |
1990 |
Smucker,M.L.,Kaul,S.,Woodfield,J.A.,Keith,J.C.,Manning,S.A.,Gascho,J.A.: :
Naturally Occurring Cardiomyopathy in the Doberman Pinscher - A Possible Large Animal Model of Human Cardiomyopathy Journal of the American College of Cardiology 16:200-206, 1990. Pubmed reference: 2358594 . |
1985 |
Miller,MS.,Saslow,NJ.,Tilley,LP.: :
ECG of the month. Boxer cardiomyopathy. J Am Vet Med Assoc 187:1002-4, 1985. Pubmed reference: 4066453 . |
1981 |
Staaden,R.V.: :
Cardiomyopathy of English Cocker Spaniels Journal of the American Veterinary Medical Association 178:1289-1292, 1981. Pubmed reference: 7275771 . |
1979 |
Liu,SK.,Maron,BJ.,Tilley,LP.: :
Canine hypertrophic cardiomyopathy. J Am Vet Med Assoc 174:708-13, 1979. Pubmed reference: 429233 . |
1979 |
Liu,SK.,Maron,BJ.,Tilley,LP.: :
Hypertrophic cardiomyopathy in the dog. Am J Pathol 94:497-508, 1979. Pubmed reference: 154845 . |