Disease Description: An adverse reaction to certain vaccines containing canine hepatitis virus (adenovirus 1) which produces a bluish discoloration to the cornea.

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Disease Symptom: About 10 days after exposure to the virus, the corneas appear blue or very hazy. Most patients squint and the eye may tear excessively. Puppies are more commonly involved than adults. Signs such as lethargy, poor appetite, nausea, jaundice (a yellowing of the skin, eyes, and membranes), bloating, or even death may be noted, if the liver is severely affected by the adenovirus infection. Sometimes the vaccination for hepatitis could actually cause the blue eye, hence the popular name 'blue eye reaction.' This reaction is seldom seen with modern vaccines.

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Treat Method: Fortunately, excellent and safe vaccines for adenovirus type 1 are available and usually administered yearly to prevent this disease. In animals not protected, life-saving treatments may be needed, including hospitalization and intravenous fluids.

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Disease Description Source: Link