Abbreviated Name: SLE
Disease Description: An autoimmune disease where antibodies form against the nuclear protein of cells. Characterized by skin lesions as well as other organ dysfunctions and blood abnormalities.
Inherit Mode: A possible role of a genetic factor in the development of SLE has been suggested for the Spitz, Shetland Sheepdog, German Shepherd Dog, Beagle, Collie, and Poodle.
Disease Symptom: Reported abnormalities in the dog include fever of unknown origin, polyarthritis, glomerulonephritis, anemia, and skin disorders. Skin signs associated with SLE include alopecia, redness, crusting, scaling, depigmentation, generalized exfoliative dermatitis, ulcers on the mucous membranes, ulcers of the paw pads, and seborrhea.
Disease Cause: -
Disease Diagnose: Manifestations of this disease are dependent upon the location of the affected cells, and diagnosis is often difficult. Partial symmetry is usually an important diagnostic clue.ANA (anti-nuclear antibodies) test is used to detect the antibodies directed against the DNA, but it often produces false readings.
Treat Method: Corticosteroid and cytotoxic drug therapy is the treatment of choice, which is often combined with treatments specific for other affected body systems. The prognosis is good from the standpoint of controlling the polyarthritis, but glomerulonephritis may progress despite therapy, occasionally resulting in death.
Breeder Advice: -
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Systemic lupus erythematosus | - | Multifactorial | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB217 | Japanese Shiba Inu | Alert, active, and attentive | 35.6-43.2 cm (male), 33-40.6 cm (female) | 8.2-10.9 kg (male), 6.8-9.1 kg (female) | Japan |
| 2016 |
Banovic,F.,Linder,K.E.,Uri,M.,Rossi,M.A.,Olivry,T.: :
Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases). Vet Dermatol :, 2016. Pubmed reference: 27747960 . DOI: 10.1111/vde.12389 . |
| 2015 |
Wilbe,M.,Kozyrev,S.V.,Farias,F.H.,Bremer,H.D.,Hedlund,A.,Pielberg,G.R.,Seppälä,E.H.,Gustafson,U.,Lohi,H.,Carlborg,Ö.,Andersson,G.,Hansson-Hamlin,H.,Lindblad-Toh,K.: :
Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease. PLoS Genet 11:e1005248, 2015. Pubmed reference: 26057447 . DOI: 10.1371/journal.pgen.1005248 . |
| 2013 |
Olivry,T.,Linder,K.E.: :
Bilaterally symmetrical alopecia with reticulated hyperpigmentation: a manifestation of cutaneous lupus erythematosus in a dog with systemic lupus erythematosus. Vet Pathol 50:682-5, 2013. Pubmed reference: 23051917 . DOI: 10.1177/0300985812463406 . |
| 2010 |
Wilbe,M.,Jokinen,P.,Truve,K.,Seppala,EH.,Karlsson,EK.,Biagi,T.,Hughes,A.,Bannasch,D.,Andersson,G.,Hansson-Hamlin,H.,Lohi,H.,Lindblad-Toh,K.: :
Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nat Genet 42:250-4, 2010. Pubmed reference: 20101241 . DOI: 10.1038/ng.525 . |
| 2009 |
Wilbe,M.,Jokinen,P.,Hermanrud,C.,Kennedy,LJ.,Strandberg,E.,Hansson-Hamlin,H.,Lohi,H.,Andersson,G.: :
MHC class II polymorphism is associated with a canine SLE-related disease complex. Immunogenetics 61:557-64, 2009. Pubmed reference: 19636550 . DOI: 10.1007/s00251-009-0387-6 . |
| 2002 |
Soulard,M.,Della,Valle,V.,Larsen,C.J.: :
Autoimmune antibodies to hnRNPG protein in dogs with systemic lupus erythematosus: Epitope mapping of the antigen Journal of Autoimmunity 18:221-229, 2002. Pubmed reference: 12126635 . |
| 1999 |
Chabanne,L.,Fournel,C.,Monestier,M.,Monier,J.C.,Rigal,D.: :
Canine systemic lupus erythematosus. Part I. Clinical and biologic aspects Compendium on Continuing Education for the Practicing Veterinarian 21:135-141, 1999. |
| 1999 |
Chabanne,L.,Fournel,C.,Rigal,D.,Monier,J.C.: :
Canine systemic lupus erythematosus. Part II. Diagnosis and treatment Compendium on Continuing Education for the Practicing Veterinarian 21:402-+, 1999. |
| 1999 |
Clercx,C.,McEntee,K.,Gilbert,S.,Michiels,L.,Snaps,F.,Jacquinet,E.,Desmecht,D.,Henroteaux,M.,Bernadina,W.E.: :
Nonresponsive generalized bacterial infection associated with systemic lupus erythematosus in a Beauceron Journal of the American Animal Hospital Association 35:220-+, 1999. Pubmed reference: 10333260 . |
| 1999 |
Olivry,T.,Savary,K.C.M.,Murphy,K.M.,Dunston,S.M.,Chen,M.: :
Bullous systemic lupus erythematosus (type I) in a dog Veterinary Record 145:165-169, 1999. Pubmed reference: 10466774 . |
| 1996 |
Felchle,L.M.,Mcphee,L.A.,Kerr,M.E.,Houston,D.M.: :
Systemic lupus erythematosus and bone marrow necrosis in a dog Canadian Veterinary Journal - Revue Veterinaire Canadienne 37:742-744, 1996. |
| 1995 |
Bell,S.C.,Carter,S.D.,May,C.,Bennett,D.: :
Antibodies to heat shock proteins in dogs with rheumatoid arthritis and systemic lupus erythematosus British Veterinary Journal 151:271-279, 1995. Pubmed reference: 7640956 . |
| 1995 |
Chabanne,L.,Fournel,C.,Caux,C.,Bernaud,J.,Bonnefond,C.,Monier,J.C.,Rigal,D.: :
Abnormalities of lymphocyte subsets in canine systemic lupus erythematosus Autoimmunity 22:1-8, 1995. Pubmed reference: 8882416 . |
| 1995 |
Monestier,M.,Novick,K.E.,Karam,E.T.,Chabanne,L.,Monier,J.C.,Rigal,D.: :
Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus Clinical and Experimental Immunology 99:37-41, 1995. Pubmed reference: 7529150 . |
| 1993 |
Bell,S.C.,Carter,S.D.,May,C.,Bennett,D.: :
IgA and IgM Rheumatoid Factors in Canine Rheumatoid Arthritis Journal of Small Animal Practice 34:259-264, 1993. |
| 1993 |
Goudswaard,J.,Schell,W.E.R.,Vantoor,A.J.,Crama,K.: :
SLE (Systemic Lupus Erythematosus) - Related Clinical Features in the Dog Tijdschrift Voor Diergeneeskunde 118:185-189, 1993. Pubmed reference: 8465348 . |
| 1993 |
Jones,D.R.E.: :
Canine Systemic Lupus Erythematosus - New Insights and Their Implications - Review Article Journal of Comparative Pathology 108:215-228, 1993. Pubmed reference: 8315051 . |