Disease Description: A clotting factor deficiency that rarely produces clinical signs. Seen in toy and standard poodles and occasionally in other breeds. Usually diagnosed incidentally during blood testing for potential bleeding disorder.
Inherit Mode: -
Disease Symptom: Affected dogs are usually asymptomatic, although a predisposition to thromboembolism is possible. In some dogs, occasional bouts of hematochezia and diarrhea may be confused with ulcerative colitis, and occasional hematoma formation has been observed in otherwise asymptomatic dogs.Urinalysis may reveal intermittent hematuria
Disease Cause: -
Disease Diagnose: The condition is usually diagnosed incidentally during routine coagulation screening test, which shows prolonged partial thromboplastin and activated clotting times, but normal thrombin clotting time and fibrinogen concentration.
Treat Method: -
Breeder Advice: -
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Factor XII deficiency | - | - | - |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB21 | Basset Fauve de Bretagne(Fawn Brittany Basset) | Smart, Cheerful, Determined | 32–38 cm (13–15 in) | France | |
CB269 | Standard Poodle | Intelligent and quick-to-please | 56-66 cm | ||
CB270 | Toy Poodle | Intelligent, eager to please, quick to learn and an affectionate, loyal pet. | under 25 cm |
2000 |
Lutze,G.,Kutschmann,K.,Aumann,V.,Hartung,K.J.,Mittler,U.: :
Combined von Willebrand disease and factor XII deficiency (vWD San Diego) in the dog and humans [German] Praktische Tierarzt 81:912-+, 2000. |
1991 |
Otto,C.M.,Dodds,W.J.,Greene,C.E.: :
Factor-XII and Partial Prekallikrein Deficiencies in a Dog with Recurrent Gastrointestinal Hemorrhage Journal of the American Veterinary Medical Association 198:129-131, 1991. Pubmed reference: 1995570 . |
1988 |
Fogh,J.M.,Fogh,I.T.: :
Inherited coagulation disorders. Vet Clin North Am Small Anim Pract 18:231-43, 1988. Pubmed reference: 3282382 . |
1986 |
Randolph,J.F.,Center,S.A.,Dodds,W.J.: :
Factor XII deficiency and von Willebrand's disease in a family of miniature poodle dogs. Cornell Vet 76:3-10, 1986. Pubmed reference: 3484442 . |
1974 |
Dodds,W.J.: :
Hereditary and acquired hemorrhagic disorders in animals. Prog Hemost Thromb 2:215-47, 1974. Pubmed reference: 4604529 . |