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hsa-miR-589-3p

miRNA ID hsa-miR-589-3p
Editing sites 3
Species Human
miRBase MIMAT0003256
PMID 29267965
Description miR-589-3p is a unique miRNA almost fully edited (100%) in normal brain and with a consistent editing decrease in glioblastoma. The edited version of miR-589-3p inhibits glioblastoma cell proliferation, migration and invasion, while the unedited version boosts cell proliferation and motility/invasion.
Disease Glioblastoma;
Sequence

Editing sites

Enzyme Editing Type Editing-Level Molecular Effect Target Change Regulation Target Relationship Correlation Editing Effect Phenotype Disease PMID
ADAR2 A-to-G Increase Retargeting of miRNA PCDH9->ADAM12 Retarget ADAM12 replaced original target PCDH9 Causative Negative The edited version of miR-589-3p inhibits glioblastoma cell proliferation, migration and invasion, while the unedited version boosts cell proliferation and motility invasion. Inhibit tumor proliferation, migration and invasion 29267965
ADAR2 A-to-G Increase Retargeting of miRNA PCDH9->ADAM12 Retarget ADAM12 replaced original target PCDH9 Causative Negative The edited version of miR-589-3p inhibits glioblastoma cell proliferation, migration and invasion, while the unedited version boosts cell proliferation and motility invasion. Inhibit tumor proliferation, migration and invasion 29267965
ADAR2 A-to-G Increase Retargeting of miRNA PCDH9->ADAM12 Retarget ADAM12 replaced original target PCDH9 Causative Negative The edited version of miR-589-3p inhibits glioblastoma cell proliferation, migration and invasion, while the unedited version boosts cell proliferation and motility invasion. Inhibit tumor proliferation, migration and invasion 29267965