EDK
Editome Disease Knowledgebase
PDE8A
| Gene symbol | PDE8A |
|---|---|
| Aliases | HsT19550 |
| Protein Name | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
| Function | |
| Species | Human |
| Editing Sites | 5 |
| Disease | Suicide with depression; Systemic lupus erythematosus; |
| Description | Altered editing may contribute to the modulation of gene regulation and ultimately, immune functions in SLE and play an important role in the initiation and propagation of SLE pathogenesis;The observation of region-specific alterations of RNA editing of PDE8A in the cortex of suicide decedents with major depression raises the possibility of providing a marker for discriminating between suicides and control groups and suggests an immune response-related brain mechanism for suicide. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | (Uniport); (NM id); (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | NT Seq Position | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | Intronic | chr15:85096753 | NA | chr15:85096753(38) | brain | NA | NA | RNA-editing providing a marker for discriminating between suicides and control groups | ||
|
A-to-I | Intronic | chr15:85096771 | NA | chr15:85096771(38) | brain | NA | NA | RNA-editing providing a marker for discriminating between suicides and control groups | ||
|
A-to-I | Intronic | chr15:85096719 | mRNA expression change | chr15:85096719(38) | T lymphocytes of normal and SLE patients | IFN | RNA-editing regulate the PDE8A1 expression | RNA editing play an important role in the initiation and propagation of SLE pathogenesis | ||
|
A-to-I | Intronic | chr15:85096720 | mRNA expression change | chr15:85096720 | T lymphocytes of normal and SLE patients | IFN | RNA-editing regulate the PDE8A1 expression | RNA editing play an important role in the initiation and propagation of SLE pathogenesis | ||
|
A-to-I | Intronic | chr15:85096750 | mRNA expression change | chr15:85096750 | T lymphocytes of normal and SLE patients | IFN | RNA-editing regulate the PDE8A1 expression | RNA editing play an important role in the initiation and propagation of SLE pathogenesis | ||
|
A-to-I | Intronic | chr15:85096752 | mRNA expression change | chr15:85096752 | T lymphocytes of normal and SLE patients | IFN | RNA-editing regulate the PDE8A1 expression | RNA editing play an important role in the initiation and propagation of SLE pathogenesis | ||
|
A-to-I | Intronic | chr15:85096753 | mRNA expression change | chr15:85096753 | T lymphocytes of normal and SLE patients | IFN | RNA-editing regulate the PDE8A1 expression | RNA editing play an important role in the initiation and propagation of SLE pathogenesis |