|
Gastric Cancer
|
Human |
NA |
Increase |
CDKN2A;CDKN2B |
CDKN2A: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported. |
Helicobacter pylori infection triggers the deletion of tumor suppressor genes CDKN2A and CDKN2B via up-regulating endogenous AID expression in the gastric mucosa. |
Increased |
Correlated |
Positive |
AID-mediated genotoxic effects occur frequently at the CDKN2b-CDKN2a locus and contribute to malignant transformation of the gastric mucosa. |
Affect mutations of cancer |
Yes |
|
|
Cholangiocarcinoma
|
Human |
TNF-α; NF-κB |
Increase |
TP53;INK4A |
TP53: This gene encodes a tumor suppressor protein containing transcriptional activation. |
Aberrant expression of AID in biliary cells results in the generation of somatic mutations in tumor related genes, including p53, c-myc, and the promoter region of the INK4A/p16 sequences. |
Increased |
Correlated |
Positive |
The proinflammatory cytokine-induced aberrant production of AID may link bile duct inflammation to an enhanced genetic susceptibility to mutagenesis, leading to cholangiocarcinogenesis. |
Promote genetic susceptibility to mutagenesis |
Yes |
|
|
Chronic Hepatitis
|
Human |
NA |
Increase |
virus HBV core protein |
NA |
AID is expressed in germinal center B cells and randomly edits C residues to U in the variable region of immunoglobulin gene loci. |
Increased |
Causative |
Negative |
AID edits HBV DNA and facilitates the mutation of HBV DNA, which may assist the virus to evolve and potentially escape from the immune responses. |
Promote virus escape from the immune resistance |
Yes |
|
EDK
Editome Disease Knowledgebase