Disease - EDK - BIG Data Center

Gene symbol	Species	Enzyme	Editing site(s)	Editing Type	PMID	Description
XIAP	Human	ADAR1	31	NA	28542129	Abrogation of ADAR1 expression or catalytic activity elicited a XIAP- dependent suppression of apoptotic response, whereas ectopic expression reversed this protective effect on cell death.
MDM2	Human	ADAR1	5	NA	28542129	Abrogation of ADAR2 expression or catalytic activity elicited a MDM2- dependent suppression of apoptotic response, whereas ectopic expression reversed this protective effect on cell death.
CCDC15	Human	ADAR1	4	A-to-I	32034135	Exon 9-included CCDC15 and exon 3-included RELL2 isoforms are oncogenic and tumor suppressive, respec- tively. More importantly, ADARs-mediated splicing changes indeed affect tumorigenesis, not merely byproducts of ADARs editing and binding.
RIMS2	Human	ADAR1	1	A-to-I	30559470	RNA editing could contribute towards aberrant synaptic formation in ASD

Virus	Disease	Enzyme	Host	PMID
BK polyomavirus	Tumorigenesis PyV-mediated tumorigenesis	APOBEC3B	Human	27147740