| URL: | https://mutanome.lerner.ccf.org |
| Full name: | My Personal Mutanome |
| Description: | My Personal Mutanome is a pharmacogenomics database that prioritizes actionable mutations for personalized cancer treatments. It aims to (1) help understand the functional roles of the somatic mutations; (2) reveal the biological consequences of the mutations at the human interactome level; (3) prioritize druggable mutations for cancer treatments and oncology drug discovery. |
| Year founded: | 2021 |
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| Country/Region: | United States |
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| University/Institution: | Lerner Research Institute |
| Address: | Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA. |
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| Country/Region: | United States |
| Contact name (PI/Team): | Feixiong Cheng |
| Contact email (PI/Helpdesk): | chengf@ccf.org |
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My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype. [PMID: 33514395]
Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols. MPM contains 490,245 mutations from over 10,800 tumor exomes across 33 cancer types in The Cancer Genome Atlas mapped to 94,563 structure-resolved/predicted protein-protein interaction interfaces ("edgetic") and 311,022 functional sites ("nodetic"), including ligand-protein binding sites and 8 types of protein posttranslational modifications. In total, 8884 survival results and 1,271,132 drug responses are obtained for these mapped interactions. MPM is available at https://mutanome.lerner.ccf.org . |