URL: | http://rcgdb.bioinf.uni-sb.de/MutomeWeb |
Full name: | Roche Cancer Genome Database |
Description: | We have constructed an integrated biological information system termed the Roche Cancer Genome Database (RCGDB) combining different human mutation databases already publicly available. |
Year founded: | 2010 |
Last update: | |
Version: | |
Accessibility: | |
Country/Region: | Germany |
Data type: | |
Data object: | |
Database category: | |
Major species: | |
Keywords: |
University/Institution: | Roche Diagnostics GmbH Pharma Research and Early Development |
Address: | |
City: | |
Province/State: | |
Country/Region: | Germany |
Contact name (PI/Team): | Jan Küntzer |
Contact email (PI/Helpdesk): | jan.kuentzer@roche.com |
The Roche Cancer Genome Database 2.0. [PMID: 21586118]
BACKGROUND: Cancer is a disease of genome alterations that arise through the acquisition of multiple somatic DNA sequence mutations. Some of these mutations can be critical for the development of a tumor and can be useful to characterize tumor types or predict outcome. |
The Roche Cancer Genome Database (RCGDB). [PMID: 20127971]
Sequence variations are being studied for a better understanding of the mechanism and development of cancer as a mutation-driven disease. The systematic sequencing of genes in tumors and technological advances in high-throughput techniques combined with efficient data acquisition methods have resulted in an explosion of available cancer genome-related data. Despite the technological progress and increase of data, improvements in the application area, for example, drug target discovery, have failed to keep pace with increased research and development spending. One reason for this discrepancy is the ever increasing number of databases and the absence of a unified access to the mutation data. Currently, researchers typically have to browse several, often highly specialized databases to obtain the required information. A more complete understanding of relations and dependencies between mutations and cancer, however, requires the availability of an efficient integrative cancer genome information system. To facilitate this, we developed the Roche Cancer Genome Database (RCGDB), a freely available biological information system integrating different kinds of mutation data. The database is the first comprehensive integration of disparate cancer genome data like single nucleotide variants, single nucleotide polymorphisms, and chromosomal aberrations (CGH and FISH). RCGDB is freely accessible via a Google-like Web interface at http://rcgdb.bioinf.uni-sb.de/MutomeWeb/. |