URL: | http://networkin.info |
Full name: | A Resource for Exploring Cellular Phosphorylation Networks |
Description: | The NetworKIN database integrates consensus substrate motifs with context modelling for improved prediction of cellular kinase–substrate relations. |
Year founded: | 2008 |
Last update: | 2007-11-02 |
Version: | v3.0 |
Accessibility: | |
Country/Region: | Canada |
Data type: | |
Data object: |
|
Database category: | |
Major species: |
|
Keywords: |
University/Institution: | Mount Sinai Hospital |
Address: | Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada |
City: | Toronto |
Province/State: | |
Country/Region: | Canada |
Contact name (PI/Team): | Rune Linding |
Contact email (PI/Helpdesk): | linding@mshri.on.ca |
NetworKIN: a resource for exploring cellular phosphorylation networks. [PMID: 17981841]
Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically assigning all 518 human kinases to all these sites is a challenging problem. The NetworKIN database (http://networkin.info) integrates consensus substrate motifs with context modelling for improved prediction of cellular kinase-substrate relations. Based on the latest human phosphoproteome from the Phospho.ELM and PhosphoSite databases, the resource offers insight into phosphorylation-modulated interaction networks. Here, we describe how NetworKIN can be used for both global and targeted molecular studies. Via the web interface users can query the database of precomputed kinase-substrate relations or obtain predictions on novel phosphoproteins. The database currently contains a predicted phosphorylation network with 20,224 site-specific interactions involving 3978 phosphoproteins and 73 human kinases from 20 families. |