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e.g., PRJCA000126;SAMC000385;tp53;EGFR; human; KaKs_Calculator; GenBank; Zhang;

All databases: 7619188

Mate Information: human iPSC exome


Mate Information: Human brain evolution

  • Accession: PRJCA000524
  • Title: Human brain evolution
  • Description: We report the application of RNA sequencing technology for high-throughput profiling of RNA expression in monkey tissues. By obtaining over four billion bases of sequence of brain, liver and muscle from MCPH1 transgenic monkey and two control monkeys. We find that brain tissue showed more differentially expressed genes compared with those in liver and muscle. Finally, we show that This result implies that the over expressed huMCPH1 may have a global impact on multiple organs of the transgenic monkey, and it has the largest impact on the brain in terms of gene numbers.
  • BasicInfo : PRJCA000524 Human brain evolution Phenotype or Genotype Evolution

Mate Information: Human Blastocyst Methylome

  • Accession: PRJCA000248
  • Title: Human Blastocyst Methylome
  • Description: We performed whole genome bisulfite sequencing (WGBS) for 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.
  • Samples: SAMC018834 SAMC017372 SAMC017371 SAMC017370 SAMC017369 SAMC017368 more
  • GSAs: CRA000114
  • BasicInfo : PRJCA000248 Human Blastocyst Methylome Epigenomics Medical

Mate Information: Human mitochondrial genome sequence project

  • Accession: PRJCA000216
  • Title: Human mitochondrial genome sequence project
  • Description: Sequenced mitochondrial genome for different tissue of human in order to find the hetero genotype
  • Samples: SAMC004504
  • GSAs: CRA000090
  • BasicInfo : PRJCA000216 Human mitochondrial genome sequence project Whole genome sequencing Medical

Mate Information: Exome chip

  • Accession: PRJCA000453
  • Title: Exome chip
  • Description: Exome chip data of human ESCC cases and controls
  • BasicInfo : PRJCA000453 Exome chip Variation Medical

Mate Information: RNA-seq of tree shrew tumors

  • Accession: PRJCA000125
  • Title: RNA-seq of tree shrew tumors
  • Description: Tree Shrew Glioblastoma Model Recapitulates Features of Human Glioblastoma
  • Samples: SAMC000383
  • GSAs: CRA000021
  • BasicInfo : PRJCA000125 RNA-seq of tree shrew tumors Transcriptome or Gene expression Model organism

Mate Information: PAR-CLIP-seq of m6A readers

  • Accession: PRJCA000273
  • Title: PAR-CLIP-seq of m6A readers
  • Description: PAR-CLIP sequencing for YTHDF1 and YTHDF3 in human HeLa cells
  • Samples: SAMC007190 SAMC007189
  • GSAs: CRA000133
  • BasicInfo : PRJCA000273 PAR-CLIP-seq of m6A readers Transcriptome or Gene expression Model organism

Mate Information: RNA m5C sequencing in human HeLa cells and mouse tissues

  • Accession: PRJCA000315
  • Title: RNA m5C sequencing in human HeLa cells and mouse tissues
  • Description: By m5C sequencing in human HeLa cells and mouse tissues, we aimed to uncover RNA distributive features in whole mRNA transcriptomes and its tissue-specific and dynamic features across mammalian transcriptomes.
  • Samples: SAMC007659 SAMC007658 SAMC007657 SAMC007656 SAMC007655 SAMC007654 more
  • GSAs: CRA000162
  • BasicInfo : PRJCA000315 RNA m5C sequencing in human HeLa cells and mouse tissues Epigenomics Model organism

Mate Information: Characterization of MV to identify senescence in human MSC

  • Accession: PRJCA000325
  • Title: Characterization of MV to identify senescence in human MSC
  • Description: The senescence in human mesenchymal stem cells (MSCs) contributes to organism aging and the development of a variety of diseases, and severely impairs therapeutic properties of MSCs as a promising cell therapy. The studies searching for efficient biomarkers that practically represent cellular senescence have attracted many attentions; however, no single marker currently provides an accurate and practically cell-free representation of cellular senescence. Here, we studied characteristics of MSC-derived microvesicles (MSC-MVs) regarding their capacities of resembling the senescence in their parental MSCs. We found that senescent late passage (LP) MSCs secreted higher levels of MSC-MVs with smaller size than did early passage (EP) MSCs, and the level of CD105+ MSC-MVs decreased with the senescence in the parental MSCs. In addition, substantially weaker ability to promote the osteogenesis in MSCs was found in LP than EP MSC-MVs. Next, our comparative analysis of RNA sequencing showed the same trend of decreasing number of highly-expressed miRNAs with passages in both MSCs and MSC-MVs, and that most of the highly-expressed genes in LP MSCs and MSC-MVs are both involved in the regulation of senescence-related diseases, such as Alzheimer's disease. Furthermore, based on the obtained miRNA, transcription factor (TF) and genes regulatory network of MSC senescence and the dataset from GEO databases, we confirmed the expression of miR-146a-5p in MSC-MVs resembled the senescent state of their parental MSCs. Our findings give support to MSC-MVs as a key factor in the senescence-associated secretory phenotype of MSCs and demonstrate that their integrated characteristics can dynamically resemble the MSC senescence state, representing a potential biomarker in precise identifying and real-time monitoring of MSC senescence in vitro and even in vivo.
  • Samples: SAMC008899
  • GSAs: CRA000160
  • BasicInfo : PRJCA000325 Characterization of MV to identify senescence in human MSC RNA sequencing and small RNA sequencing Medical

Mate Information: Human-specific changes in the transcriptome composition of neocortical layers

  • Accession: PRJCA000257
  • Title: Human-specific changes in the transcriptome composition of neocortical layers
  • Description: The transcriptome of the cortical layers and adjacent white matter in the prefrontal cortex of humans, chimpanzees and rhesus macaques was characterized using unsupervised sectioning followed by RNA sequencing.
  • Samples: SAMC006960 SAMC006959 SAMC006958 SAMC006957
  • GSAs: CRA000120
  • BasicInfo : PRJCA000257 Human-specific changes in the transcriptome composition of neocortical layers Transcriptome or Gene expression Evolution