BIG Search

BIG Search is a scalable text search engine built based on ElasticSearch (a highly scalable open-source full-text search and analytics engine based on Apache Lucene). It features cross-domain search and facilitates users to gain access to a wide range of biomedical data, not only from BIGD databases but also partner databases throughout the world.

e.g., PRJCA000126;SAMC000385;tp53;EGFR; human; KaKs_Calculator; GenBank

All databases: 243

tool: MEGSA

  • basicInfo: , we identified a MEGS with five genes (FLT3, IDH2, NRAS, KIT, and TP53) and a MEGS (NPM1, TP53, and... cancer, we identified a significant MEGS consisting of TP53 and four infrequently mutated genes (ARID1A

tool: Hotspot3D

  • basicInfo: tissue specificity. In addition, we identified 369 rare mutations in genes including TP53, PTEN, VHL


  • basicInfo: suppressor genes TP53 and NF1 and in a candidate tumor suppressor gene CDK12. We also used ABSOLUTE to infer

tool: Differential Gene Correlation Analysis

  • basicInfo: only identifies key changes in the regulatory relationships between TP53 and PTEN and their target

tool: INDELseek

  • basicInfo: , BRCA2 and TP53 mutations with gained or rescued protein-truncating effects.INDELseek is an accurate

tool: pathTiMEx

  • basicInfo: , such as the temporal order among pathways which include APC, KRAS, and TP53 in colorectal cancer

tool: ITDseek

  • basicInfo: mutations (range 1-5) were detected per positive sample. TP53 gene mutations were found in 3 out of 4