BIG Search

BIG Search is a scalable text search engine built based on ElasticSearch (a highly scalable open-source full-text search and analytics engine based on Apache Lucene). It features cross-domain search and facilitates users to gain access to a wide range of biomedical data, not only from BIGD databases but also partner databases throughout the world.

e.g., PRJCA000126;SAMC000385;tp53;EGFR; human; KaKs_Calculator; GenBank

All databases: 4654689

tool: Prism

  • basicInfo: The rapid growth of sequencing technologies has greatly contributed to our understanding of human, diploid nature of the human genome. Here we describe statistically aided, long-read haplotyping (SLRH, phased information contained in long genomic fragments analyzed by short-read sequencing. For a human, three human genomes into long haplotype blocks 0.2-1 Mbp in length. We apply our method to determine, allele-specific methylation patterns in a human genome and identify hundreds of differentially

tool: microRNA script

  • basicInfo: that human can absorb dietary microRNAs from animal and plant origins while the mechanism remains, unknown. Compelling evidences of microRNAs from rice, milk, and honeysuckle transported to human blood, exogenous microRNAs can be transferred into human circulation and possibly exert functions in, characterize human circulating microRNAs and infer the likelihood that a microRNA will get, transferred into human circulation. For example, 345 dietary microRNAs have been predicted as highly

tool: BLAST Read and Operational Taxonomic Unit Consensus Classifier

  • basicInfo: Eukaryotic microorganisms are important but understudied components of the human microbiome. Here, eight well-characterized human stool samples. A software pipeline, pyrosequence data. This study provides a well-characterized tool kit for sequence-based enumeration of eukaryotic organisms in human microbiome samples.

tool: VirusSeq

  • basicInfo: sites in the human genome using next-generation sequencing data. We evaluated VirusSeq on whole,-transcriptome sequencing (RNA-Seq) data of 256 human cancer samples from The Cancer Genome Atlas. Using, sequencing data of human tissue.VirusSeq has been implemented in PERL and is available at http

tool: P-clouds

  • basicInfo: consensus element sequences. Using this approach, about half of the human genome has been previously, additional repetitive sequences in the human genome, thus suggesting that 66%-69% of the human genome is,), to detect different sized fragments of the highly abundant human Alu and MIR SINEs. RM can have,, and using it we identified ∼100 Mb of previously unannotated human elements. ESP estimates of new, the human genome consists of substantially more repetitive sequence than previously believed.

tool: SGP2

  • basicInfo: The completion of the sequencing of the mouse genome promises to help predict human genes with, number of false-positive genes in the human genome. Sequence conservation at the protein level with the, genes by comparing the human and mouse genomes is assessed on a number of data sets, including, single-gene data sets, the highly curated human chromosome 22 predictions, and entire genome predictions, human and mouse by comparing the genomes of these two species. Our results suggest that another few

tool: SMIRP

  • basicInfo: attention recently. However, the majority of studies have focused on the human genome. Previous studies, have demonstrated that sensitivity (correctly detecting true miRNA) is sustained when human-trained, specificity (the ability to correctly reject non-miRNA sequences) in non-human genomes. Considering the, prevents the application of most existing tools to non-human genomes, as the number of false,. Substantial improvements in specificity and precision are obtained for four non-human test species

tool: SMRT-SV

  • basicInfo: The human genome is arguably the most complete mammalian reference assembly, yet more than 160, haploid human genome (CHM1) using single-molecule, real-time DNA sequencing. We close or extend 55,% of the remaining interstitial gaps in the human GRCh37 reference genome--78% of which carried long, less than 5 kilobases in size. Compared to the human reference, we find a significant insertional bias, suggest a greater complexity of the human genome in the form of variation of longer and more complex

tool: Hybrid Structural variant Assembly

  • basicInfo: Achieving complete, accurate, and cost-effective assembly of human genomes is of great importance, human genomes and the limitations of existing sequencing technologies call for the development of, structural variants (SVs) in human genomes. By identifying homologous SV-containing reads from, effectively solved to enhance the assembly of structurally altered regions in human genomes. We used data, generated from a haploid hydatidiform mole genome (CHM1) and a diploid human genome (NA12878) to test

tool: PHENOstruct

  • basicInfo: The human phenotype ontology (HPO) was recently developed as a standardized vocabulary for, describing the phenotype abnormalities associated with human diseases. At present, only a small fraction of, human protein coding genes have HPO annotations. But, researchers believe that a large portion of