BIG Search

BIG Search is a scalable text search engine built based on ElasticSearch (a highly scalable open-source full-text search and analytics engine based on Apache Lucene). It features cross-domain search and facilitates users to gain access to a wide range of biomedical data, not only from BIGD databases but also partner databases throughout the world.

e.g., PRJCA000126;SAMC000385;tp53;EGFR; human; KaKs_Calculator; GenBank

All databases: 307

tool: Integrating Molecular Profiles with ACtionable Therapeutics

  • basicInfo: Cancer Genome Atlas (TCGA) lung adenocarcinoma samples with known EGFR mutations. We also used... known EGFR mutations in the TCGA lung adenocarcinoma samples. IMPACT linked these EGFR mutations to... the appropriate FDA-approved EGFR inhibitors. For the melanoma patient samples, we identified NRAS

tool: Hotspot3D

  • basicInfo: , EGFR, and FBXW7 and 99 medium-recurrence mutations in genes such as RUNX1, MTOR, CA3, PI3, and... validated our predictions in EGFR using high-throughput phosphorylation data and cell-line-based

tool: Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout

  • basicInfo: conditions. Using public datasets, MAGeCK identified novel essential genes and pathways, including EGFR in

tool: Meerkat

  • basicInfo: loss of CDKN2A/B and gain of EGFR in glioblastoma, revealing that these alterations can result from

tool: TAGCNA

  • basicInfo: . TAGCNA identifies SCEs that are known to be involved with proto-oncogenes (e.g. EGFR, CDK4) and

tool: VarDict

  • basicInfo: known driver mutations in KRAS, EGFR, BRAF, PIK3CA and MET in 16% more patients than previously

tool: Epidaurus

  • basicInfo: cancer-associated genes including EGFR. The prebuilt epigenetic dataset from commonly used cell lines

tool: CMDS

  • basicInfo: , respectively, and successfully identified known regions of CNA associated with EGFR, KRAS and other

tool: Graph Protein Amino acid Clustering

  • basicInfo: clusters in well known oncogenes such as EGFR and KRAS. Further, by utilizing graph theory to account for

tool: identification of Protein Amino acid Clustering

  • basicInfo: PI3KC α. Further, by utilizing the tertiary structure, our algorithm also identifies clusters in EGFR