Methbank - 5mrC

All studies about 5mrC


Studies RNA type Species Tissue
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
  • tRNA
  • mRNA
  • other non-coding RNA
  • Homo sapiens
  • HeLa cells
Whole Exome Sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome
  • tRNA
  • Homo sapiens
  • Dermal fibroblasts
NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation
  • Homo sapiens
  • U2OS cell
NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs
  • tRNA
  • mRNA
  • ncRNA
  • Homo sapiens
  • COS7 or HEK293 cells
  • Human fibroblasts
The human tRNA m (5) C methyltransferase Misu is multisite-specific
  • tRNA
  • Homo sapiens
  • Expression of human Misu in Escherichia coli and purification of the protein
  • doing incubation in vitro
NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly
  • rRNA
  • Mus musculus
  • Mouse heart
The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation
  • tRNA
  • Mus musculus
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
  • tRNA
  • Mus musculus
  • Testis
  • Liver
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan
  • rRNA
  • Drosophila melanogaster
  • Caenorhabditis elegans
  • Saccharomyces cerevisiae
Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively
  • rRNA
  • Saccharomyces cerevisiae
Conservation of tRNA and rRNA 5-methylcytosine in the kingdom Plantae
  • tRNA
  • rRNA
  • Nannochloropsis oculata
  • Caulerpa taxifolia
  • Brassica rapa
  • Ginkgo biloba
  • Triticum turgidum
  • Arabidopsis thaliana
  • A. thaliana: seedlings
  • or floral buds
  • T. durum: flag leaf
  • B. rapa: shoot apexes
  • G. biloba: shoot apexes
  • C. taxifolia: fronds
  • N. oculata: log phase growth cells
A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability.
  • rRNA
  • Saccharomyces cerevisiae
Transcriptome-wide mapping of 5-methylcytidine RNA modifications in bacteria, archaea, and yeast reveals m5C within archaeal mRNAs
  • rRNA
  • tRNA
  • mRNA
  • Escherichia coli
  • Bacillus subtilis
  • Sulfolobus solfataricus
  • Saccharomyces cerevisiae
Identification of differentially methylated regions during vernalization revealed a role for RNA methyltransferases in bolting
  • total RNA
  • Beta vulgaris altissima
  • Arabidopsis thaliana
  • Beta vulgaris altissima shoot apical meristems
  • Arabidopsis plants
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling
  • tRNA
  • Schizosaccharomyces pombe
The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate
  • tRNA
  • Mus musculus
  • Dorsal skin
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
  • tRNA
  • Drosophila melanogaster
  • Mus musculus
  • Drosophila ovary
  • Drosophila S2 cells
  • Mouse embryonic fibroblasts
Stem cell function and stress response are controlled by protein synthesis
  • tRNA
  • Homo sapiens
  • Mus musculus
  • K5-Sos mouse skin tumours
NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation
  • mRNA
  • Homo sapiens
  • HeLa cells
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders
  • tRNA
  • Homo sapiens
  • Mus musculus
  • Mouse back skin
  • Human dermal fibroblast
Identification of direct targets and modified bases of RrNA cytosine methyltransferases
  • tRNA
  • Homo sapiens
  • Mus musculus
  • HeLa cells
  • Mouse embryonic fibroblasts (MEFs)
NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs
  • tRNA
  • Homo sapiens
  • HEK293 cells
  • HeLa CCL2 cells
Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6
  • tRNA
  • Homo sapiens
Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain
  • total poly(A) RNA
  • nuclear poly(A) RNA
  • Mus musculus
  • Embryonic stem cells
  • Adult brain
Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs
  • mRNAs
  • noncoding RNAs
  • Arabidopsis thaliana
  • siliques
  • seedling shoots
  • and roots
Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility
  • total RNA
  • Homo sapiens
  • Mus musculus
  • NES cell line (Sai1)
  • Neuroepithelial-like stem cells (AF22)
  • Mouse frontal brain