MethBank - Human

MethBank-Human

MethBank-Human is a database focusing on human epigenetic aging, integrating mass blood samples from healthy people at different ages. It provides reference methylomes for healthy people in different age groups. MethBank features the identification of age-specific differentially methylated cytosines (aDMCs) or regions (aDMRs), the detection of methylation sites closely associated with age and methylation sites with constant methylation levels across different ages, and the visualization of methylation patterns. Ongoing efforts are focused on the relationship between methylation and aging and providing an important resource for the epigenetic studies on human developments and diseases.

Data sources

Project ID GEO accession Project name Platform Submitter Year Sample NO.
PRJNA154949 GSE32148 DNA methylation in peripheral blood from individuals with Crohns' disease or ulcerative colitis and normal controls Illumina HumanMethylation450 BeadChip R. Alan Harris 2011 19
PRJNA173415 GSE40279 Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates Illumina HumanMethylation450 BeadChip Justin Guinney 2012 656
PRJNA218212 GSE50660 Cigarette Smoking Reduces DNA Methylation Levels at Multiple Genomic Loci but the Effect is Partially Reversible upon Cessation Illumina HumanMethylation450 BeadChip Tsun-Po Yang 2013 464
PRJNA219744 GSE51032 EPIC-Italy at HuGeF Illumina HumanMethylation450 BeadChip Gianluca Campanella 2013 327
PRJNA222982 GSE51388 Intra-MZ pair discordance and longitudinal variation of whole-genome scale DNA methylation in adults Illumina HumanMethylation450 BeadChip Na Zhang 2013 60
PRJNA226710 GSE52113 H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells Illumina HumanMethylation450 BeadChip Agustin F Fernandez 2013 24
PRJNA230928 GSE53128 Differential Methylation Of The TRPA1 Promoter In Pain Sensitivity: DNA methylation 450k array Illumina HumanMethylation450 BeadChip Jordana Bell 2013 43
PRJNA232852 GSE53740 An Epigenetic Signature in Peripheral Blood Associated with Neurodegenerative Tauopathy and the Risk-Associated Haplotype on 17q21.31 Illumina HumanMethylation450 BeadChip Giovanni Coppola 2013 193
PRJNA255468 GSE59509 Genome-wide methylation profiles of forensically relevant body fluids Illumina HumanMethylation450 BeadChip Hwan Young Lee 2014 12
PRJNA260356 GSE61151 Temporal stability and determinants of white blood cell DNA methylation in the Breakthrough Generations Study Illumina HumanMethylation450 BeadChip James M Flanagan 2014 184
PRJNA261326 GSE61496 Epigenetic signature of birth-weight discordance in Danish twins Illumina HumanMethylation450 BeadChip Qihua Tan 2014 310
PRJNA271158 GSE64495 DNA methylation profiles of human blood samples from a severe developmental disorder and controls Illumina HumanMethylation450 BeadChip Steve Horvath 2014 106
PRJNA274570 GSE65638 Epigenome analysis of female identical twins Illumina HumanMethylation450 BeadChip Bingbing Xie 2015 16
PRJNA280835 GSE67751 Blood Illumina Inf 450 DNA methylation samples from HIV+ and HIV- human subjects Illumina HumanMethylation450 BeadChip Steve Horvath 2015 69
PRJNA295045 GSE72773 DNA methylation profiles of human blood samples from older Tsimane, Caucasians, and Hispanics Illumina HumanMethylation450 BeadChip Steve Horvath 2015 310
PRJNA295047 GSE72775 DNA methylation profiles of human blood samples from Hispanics and Caucasians Illumina HumanMethylation450 BeadChip Steve Horvath 2015 335
PRJNA295051 GSE72777 DNA methylation profiles of human blood samples from younger Tsimane and Caucasians Illumina HumanMethylation450 BeadChip Steve Horvath 2015 46
PRJNA296032 GSE73103 Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers Illumina HumanMethylation450 BeadChip Sarah Amandine Caroline Voisin 2015 355
PRJNA314912 GSE79056 Nashville Birth Cohort Illumina HumanMethylation450 BeadChip Varun Kilaru 2016 36
PRJNA318493 GSE80283 Victorian Infant Collaborative Study Illumina HumanMethylation450 BeadChip Varun Kilaru 2016 183
PRJNA318761 GSE80310 UGA Folate and Pregnancy Illumina HumanMethylation450 BeadChip Varun Kilaru 2016 24
PRJNA325642 GSE83334 Longitudinal study of DNA methylation during the first 5 years of life Illumina HumanMethylation450 BeadChip Agustin F Fernandez 2016 30
PRJNA345217 GSE87571 Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan Illumina HumanMethylation450 BeadChip ├ůsa Johansson 2016 729
PRJNA350276 GSE89093 DNA methylome analysis of human peripheral blood samples in cancer discordant monozygotic twin-pairs Illumina HumanMethylation450 BeadChip Tim Spector 2016 46