GAS5, functions as a ceRNA to regulate hZIP1
Approved symbol: GAS5
Approved name: GAS5: growth arrest specific 5
Alias symbols: SNHG2, NCRNA00030
HGNC ID: HGNC: 16355
LncBook ID: HSALNT0017702
Ensembl ID: ENSG00000234741
RefSeq ID: NR_002578
GAS5 is one of the lncRNAs in a six-lncRNA signature that is independently associated with the prognosis of GBM patients.
GAS5 is necessary and sufficient for growth arrest in human peripheral blood T-cells. It functions by controlling apoptosis and the cell cycle in lymphocytes . In some cell lines certain GAS5 isoforms act to sensitise the cells to apoptosis but can't induce apoptosis on their own. In other cells types Gas5 can both induce apoptosis and growth arrest and sensitise the cells to further apoptosis . GAS5 carries out its function by binding the DNA binding domain of the glucocorticoid receptor (GR) with a sequence that mimmics the glucocorticoid response element (GRE). GAS5 is translocated into the nucleus bound to the GR where it prevents GR from binding GREs and regulating transcription of target genes including apoptosis inhibitors . GAS5 also appears to repress the action of many steroid hormone receptors, showing some similarities to another lncRNA SRA . GAS5 is a snoRNA host and a functional RNA. Function does not require putative but nonconserved ORF, or the intronic snoRNAs .
GAS5 can be regulated by mTOR, with mTOR (which promotes cellular proliferation) acting to inhibit the function of GAS5 . Expression of GAS5 mRNA is regulated at the posttranscriptional level during growth and at the transcriptional level in differentiated cells .
- Autoimmune disease 
- B-cell neoplasms 
- Breast cancer 
- Kidney cancer 
- Lymphoma 
- Prostate cancer melanoma 
- Systemic lupus erythaematosus 
GAS5 is widely expressed in adult tissues and over embryonic development . Transcript undergoes post-transcriptional regulation, highly unstable but stabilised by growth arrest, serum starvation and inhibition of protein synthesis . Associates with ribosomes in the cytoplasm . Localises to both the nucleus and the cytoplasm . Down-regulated in breast cancer . Transcript was classified as unstable with a half-life >4 hr in human Hela cells .
>gi|60674|ref|NR_002578.3| Homo sapiens growth arrest specific 5 (GAS5), transcript variant 1, long non-coding RNA
Labs working on this lncRNA
- European Molecular Biology Laboratory, Heidelberg, Germany
- Institute for Science and Technology in Medicine and School of Life Sciences, Huxley Building, Keele University, Keele, United Kingdom
- King's College London, Department of Haematological Medicine, The Rayne Institute, London, United Kingdom (F.F.)
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