UCA1 Urothelial cancer associated 1 is a long noncoding RNA that is involved in the growth and tumorigenesis of various kinds of human cancer.
Approved symbol: UCA1
Approved name: urothelial cancer associated 1
HGNC ID: HGNC:37126
Previous names: urothelial cancer associated 1 (non-protein coding)
Alias symbols: LINC00178; CUDR; UCAT1; onco-lncRNA-36
Alias names: long intergenic non-protein coding RNA 178; cancer up-regulated drug resistant
RefSeq ID: NR_015379
LncBook ID: HSALNT0256354
UCA1 is three exon long noncoding RNA that is located on human chromosome 19p13.12. UCA1 is spliced and polyadenylated . Multiple isoforms of UCA1 exist (1.4kb, 2.2kb and 2.7kb). The 2.2kb isoform contains an extended final exon compared to the 1.4kb isoform while the 2.7kb isoform has not been characterised . Sequence is mainly repeat elements. Initiates in an LTR, exons sample pieces of a HERV-H element and longer 2.2kb isoform contains a second LTR at the 3' end .
Functions of 1.4kb and 2.2kb isoforms have been investigated, both appear to promote and enhance tumourigenesis . Over-expression of 1.4kb isoform enhanced tumorigenic behavior of bladder cancer cells in-vitro and in-vivo. Increased drug resistance and cell motility . Overexpression of 2.2kb isoform caused resistance to drug induced apoptosis, potentially by downregulation of caspase 3 levels . 2.2kb isoform promoted transformation in-vitro, possibly because resistance to apoptosis is an important step in tumourigenesis .
UCA1 modulate MDR1 by a model system of leukemia cell lines with a gradual increase of MDR1 expression and IM resistance. UCA1 competes with 3' UTR of MDR1 mRNA for common miR-16 to regulate MDR1 expression. Overexpression of UCA1 increased MDR1 expression to promote Imatinib (IM) resistance of chronic myeloid leukemia (CML) cells .
Enhanced expression of UCA1 is involved in cancer metastasis tongue squamous cell carcinoma .
UCA1 improve the cell migration, invasion and induce cisplatin resistance .
overexpression of UCA1 promotes osteosarcoma initiation and progression .
UCA1 promotes hepatocellular carcinoma progression through inhibition of miR-216b by FGFR1/ERK signaling pathway .
Widely expressed in embryonic development and placenta . Low or no expression in normal adult tissue but highly upregulated in cell lines resistant to drug induced apoptotic cell death and bladder, colon and lung cancer , .
Elevated expression of UCA1 is found in ovarian cancer tissues .
UCA1 is overexpressed in osteosarcoma .
High expressed in gastric cancer.
|Experiment||Forward primer||Reverse primer|
|Real Time PCR||5′‐GACCCTACCCGGTCATTTATAG‐3′||5′‐CTGATGGGCATGGCTTTATTC‐3′|
Found in humans. May be present in other primates but not in more distantly related mammals 
- Bladder cancer 
- Hepatocellular carcinoma 
- Osteosarcoma 
- Overian Cancer 
- Pancreaticobiliary maljunction 
- Renal cell carcinoma 
- Tongue squamous cell carcinomas 
- gastric cancer
Labs working on this lncRNA
- Department of Clinical Laboratory, Zhongshan Hospital of Xiamen University , Xiamen, Fujian Province, China.
- Department of Cardiothoracic Surgery, The Affiliated Dongnan Hospital of Xiamen University , Xiamen, Fujian Province, China.
- Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
- Department of Urology, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
- The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
- Department of Gynecology, Shaannxi Provincial People’s Hospital, Xi’an 710068, China.
- Department of Pediatrics, Second Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an 710054, China.
- Center for Clinical Laboratory, Shaanxi Provincial People’s Hospital, Xi’an 710068, China.
- Central Laboratory, Shaanxi Provincial People’s Hospital, Xi’an 710068, China.
- Wang XS, Zhang Z, Wang HC, Cai JL, Xu Q W, Li MQ et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma[J]. Clinical cancer research. 2006, 12(16):4851-4858.
- Wang F, Li X, Xie XJ, Zhao L, & Chen W. UCA1, a non‐protein‐coding RNA up‐regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion[J]. FEBS letters. 2008, 582(13):1919-1927.
- Tsang W P, Wong T W L, Cheung A H H, et al. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR[J]. Rna. 2007.
- Xiao Y, Jiao C, Lin Y, Chen M, Zhang J, Wang J et al. lncRNA UCA1 contributes to imatinib resistance by acting as a ceRNA against miR-16 in chronic myeloid leukemia cells[J]. DNA and cell biology. 2017, 36(1):18-25.
- Yang QQ, Deng YF. Long non-coding RNAs as novel biomarkers and therapeutic targets in head and neck cancers[J]. International journal of clinical and experimental pathology. 2014, 7(4):1286.
- Wang F, Zhou J, Xie X, Hu J, Chen L, Hu Q et al. Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells[J]. Neoplasma. 2015.
- Li W, Xie P, Ruan W. Overexpression of lncRNA UCA1 promotes osteosarcoma progression and correlates with poor prognosis[J]. Journal of bone oncology. 2016, 5(2):80-85.
- Wang F, Ying HQ, He BS, Pan YQ, Deng QW, Sun HL et al. Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway[J]. Oncotarget. 2015, 6(10):7899.
- Fang Z, Wu L, Wang L, Yang Y, Meng Y & Yang H. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis[J]. Oral surgery, oral medicine, oral pathology and oral radiology. 2014, 117(1):89-95.
- Li Y, Wang T, Li Y, Chen D, Yu Z, Jin L et al. Identification of long-non coding RNA UCA1 as an oncogene in renal cell carcinoma[J]. Molecular medicine reports. 2016, 13(4):3326-3334.
- Cao WJ, Wu HL, He BS, et al. Analysis of long non-coding RNA expression profiles in gastric cancer[J]. World J Gastroenterol, 2013, 19: 3658-3664.
- Kaneko K, Ito Y, Ono Y, Tainaka T, Tsuchiya H, Shimoyama Y, et al. Gene expression profiling reveals upregulated UCA1 and BMF in gallbladder epithelia of children with pancreaticobiliary maljunction[J]. Journal of pediatric gastroenterology and nutrition. 2011, 52(6):744-750.