1. LncRNA Integration and Identification

Data Item Number
Total genes 140,362
Total transcripts 270,044
Transcripts integrated from existing databases 247,246
Novel transcripts identified based on RNA-Seq data 21,815
Functional lncRNAs supported by experimental evidence 1,867

2. Transcript Number of Genes

3. Exon Number of Transcripts

4. Transcript Classification

5. Multi-omics Analysis

Item Data Results
Expression HPA: 32 normal tissues, 122 samples
GTEx: 53 normal tissues, 11,688 samples
101,123 expressed lncRNA transcripts; 819 HK lncRNAs, 49,115 TS lncRNAs
Methylation TCGA: 9 cancers, 47 samples
ENCODE: brain tissue, 1 sample
Both promoter and body region methylation level of 270,044 lncRNA transcripts
Variation 1000 Genomes Project 92,725,757 SNPs
Interaction 270,044 lncRNAs 128,392,451 lncRNA-miRNA interactions
Data Item LncRNA Number Association Number Literature Number
LncRNA-function association 1,653 3,762 2,501
LncRNA-disease association 1,502 3,772 2,337

7.LncRNA-Disease Association

MeSH Ontology Association Number LncRNA Number
Neoplasms 2,888 1,077
Digestive System Diseases 888 427
Male Urogenital Diseases 423 176
Female Urogenital Diseases and Pregnancy Complications 403 195
Respiratory Tract Diseases 339 224
Skin and Connective Tissue Diseases 229 165
Endocrine System Diseases 260 129
Cardiovascular Diseases 242 155
Congenital, Hereditary, and Neonatal Diseases and Abnormalities 217 150
Nervous System Diseases 214 103
Immune System Diseases 126 69
Hemic and Lymphatic Diseases 117 63
Mental Disorders 101 52
Musculoskeletal Diseases 81 66
Nutritional and Metabolic Diseases 57 36
Stomatognathic Diseases 48 34
Otorhinolaryngologic Diseases 43 31
Virus Diseases 38 25
Pathological Conditions, Signs and Symptoms 24 21
Eye Diseases 19 11
Bacterial Infections and Mycoses 11 11
Physiological Phenomena 9 5
Behavior and Behavior Mechanisms 8 7
Cell Physiological Phenomena 5 4
Chemically-Induced Disorders 5 3
Parasitic Diseases 5 2
Occupational Diseases 3 3
Disorders of Environmental Origin 2 2

8. LncRNA-Function Association

Data Item Association Number LncRNA Number
Functional Mechanism (n =6) transcriptional regulation 397 235
ceRNA 182 93
translational control 19 17
splicing regulation 19 9
protein localization 6 6
RNAi 3 3
Biological Process (n = 2) pathogenic process 3,598 157
developmental process 53 48
Tag (n = 8) biomarker 943 523
therapy target 373 196
snp in lncRNA 144 84
oncogene 113 62
suppressor 104 58
stress action 12 12
miRNA precursor 7 7
evolution 2 2