PMID Title Journal Year Target
24556721 RNA editome imbalance in hepatocellular carcinoma. Cancer Res 2014
23291631 Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med 2013
23748106 Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing. Int J Biochem Cell Biol 2013
24302582 Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma. Cancer Res 2014
14985749 Glutamate receptors: RNA editing and death of motor neurons. Nature 2004
28167531 Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma. J Biol Chem 2017
14559151 Glutamate receptor RNA editing: a molecular analysis of GluR2, GluR5 and GluR6 in human brain tissues and in NT2 cells following in vitro neural differentiation. Brain Res Mol Brain Res 2003
24679603 Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease. Neurobiol Aging 2014
22266371 GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q/R RNA editing in the lens. Biochem Biophys Res Commun 2012
19447293 Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. Neurosci Res 2009
16225946 Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA. Neurosci Res 2006
14757529 Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains. Brain Res Dev Brain Res 2004
11442354 RNA editing at the Q/R site for the glutamate receptor subunits GLUR2, GLUR5, and GLUR6 in hippocampus and temporal cortex from epileptic patients. Neurobiol Dis 2001
8616634 Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia. Brain Res 1995
7523595 RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. J Neurochem 1994
7529592 Differential RNA editing efficiency of AMPA receptor subunit GluR-2 in human brain. Neuroreport 1994
21110885 ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics. Mol Neurodegener 2010
9450685 Characterization of RNA editing of the glutamate-receptor subunits GluR5 and GluR6 in granule cells during cerebellar development. Brain Res Mol Brain Res 1997
11414791 High abundance of GluR1 mRNA and reduced Q/R editing of GluR2 mRNA in individual NADPH-diaphorase neurons. Mol Cell Neurosci 2001
15093687 Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy. Brain Res Mol Brain Res 2004
28265714 A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment. Psychopharmacology (Berl) 2017
18554725 RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 2008
18045717 Serotonin2C receptor mRNA editing in neuropathic pain model. Neurosci Res 2008
19036977 Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci 2008
17554622 Editing of AMPA and serotonin 2C receptors in individual central neurons, controlling wakefulness. Cell Mol Neurobiol 2007
26950265 Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci 2016
14602721 RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms. J Biol Chem 2004
25807502 APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts. PLoS One 2015
8808692 Analysis of possible WT1 RNA processing in primary Wilms tumors. Oncogene 1996
27595325 Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med 2016
27907896 Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res 2017
20126463 Alternative splicing and extensive RNA editing of human TPH2 transcripts. PLoS One 2010
28035363 ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma. Int J Oncol 2017
23543219 Insulin-like growth factor-binding protein-7 (IGFBP7) transcript: A-to-I editing events in normal and cancerous human keratinocytes. Arch Dermatol Res 2013
23324600 RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling. RNA Biol 2013
19908260 Human BLCAP transcript: new editing events in normal and cancerous tissues. Int J Cancer 2010
9012403 A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors. Am J Hum Genet 1997
26080435 PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proc Natl Acad Sci U S A 2015
25499081 RNA over-editing of BLCAP contributes to hepatocarcinogenesis identified by whole-genome and transcriptome sequencing. Cancer Lett 2015
16404425 Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa. Br J Cancer 2006
20843408 Increased A-to-I RNA editing of the transcript for GABAA receptor subunit α3 during chick retinal development. Vis Neurosci 2010
11001933 RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. Hum Mol Genet 2000
24663214 RNA editing in RHOQ promotes invasion potential in colorectal cancer. J Exp Med 2014
22525274 ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis. Oncogene 2013
29203771 Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. Nat Commun 2017
24386085 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. PLoS One 2013
25686251 Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. Nat Cell Biol 2015
27292188 ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell 2016
23093778 Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. J Clin Invest 2012
29386624 A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression. Nat Commun 2018
29267965 ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion. Nucleic Acids Res 2018
15039537 Hepatitis D virus RNA editing is inhibited by a GFP fusion protein containing a C-terminally deleted delta antigen. J Gen Virol 2004
12237434 Initiation of hepatitis delta virus (HDV) replication: HDV RNA encoding the large delta antigen cannot replicate. J Gen Virol 2002
11514728 Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela. J Gen Virol 2001
9672172 Hepatitis delta genotypes in chronic delta infection in the northeast of Spain (Catalonia). J Hepatol 1998
9528763 Hepatitis delta virus RNA editing is highly specific for the amber/W site and is suppressed by hepatitis delta antigen. Mol Cell Biol 1998
19941396 Identification of cellular partners of Influenza A virus (H5N1) non-structural protein NS1 by yeast two-hybrid system. Acta Virol 2009
26989717 Construction and eukaryotic expression of recombinant large hepatitis delta antigen. Rep Biochem Mol Biol 2013
11870382 Varied assembly and RNA editing efficiencies between genotypes I and II hepatitis D virus and their implications. Hepatology 2002
26568914 Hepatitis delta virus: A fascinating and neglected pathogen. World J Virol 2015
25416632 Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity. Genome Biol 2014
25838269 Ebola Virus GP Gene Polyadenylation Versus RNA Editing. J Infect Dis 2015
26299853 [Ebola hemorrhagic fever: Properties of the pathogen and development of vaccines and chemotherapeutic agents]. Mol Biol (Mosk) 2015
23341589 RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase. Proc Natl Acad Sci U S A 2013
23686695 Deletion of the D domain of the human parainfluenza virus type 3 (HPIV3) PD protein results in decreased viral RNA synthesis and beta interferon (IFN-β) expression. Virus Genes 2013
1310183 RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3. Virology 1992
23923604 Cloning and expression analysis of multiple proteins encoding P gene of Newcastle disease virus. Indian J Exp Biol 2013
18490071 Genetic variability and mRNA editing frequencies of the phosphoprotein genes of wild-type measles viruses. Virus Res 2008
8725103 Synthesis of leader RNA and editing of P mRNA during transcription by rinderpest virus. Virus Res 1996
8277263 RNA editing in Newcastle disease virus. J Gen Virol 1993
17913828 RNA editing of the human herpesvirus 8 kaposin transcript eliminates its transforming activity and is induced during lytic replication. J Virol 2007
29956457 Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis. J Cell Mol Med 2018
29996118 CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients. Cell Physiol Biochem 2018
29592874 Decreased A-to-I RNA editing as a source of keratinocytes’ dsRNA in psoriasis RNA 2018
30087110 RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure EMBO J 2018
28411194 Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers. Genome Res. 2017
27494666 ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity. Cell Stem Cell 2016
23403535 A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J. Alzheimers Dis. 2013
29527417 Global analysis of A-to-I RNA editing reveals association with common disease variants. PeerJ 2018
25582055 Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. Genome Biol. 2015
26640150 Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. Oncogene 2016
23979837 Kainate receptor RNA editing is markedly altered by acute spinal cord injury. J. Mol. Neurosci. 2013
12080062 Two novel transcripts for human endothelin B receptor produced by RNA editing/alternative splicing from a single gene. J. Biol. Chem. 2002
21569822 Increased RNA editing in EAAT2 pre-mRNA from amyotrophic lateral sclerosis patients: involvement of a cryptic polyadenylation site. Neurosci. Lett. 2011
10487495 Familial hypercholesterolemia. Acceptor splice site (G-->C) mutation in intron 7 of the LDL-R gene: alternate RNA editing causes exon 8 skipping or a premature stop codon in exon 8. LDL-R(Honduras-1) [LDL-R1061(-1) G-->C]. Atherosclerosis 1999
27373511 ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. Gastroenterology 2016
28188287 A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. J. Biol. Chem. 2017
17369310 Editing modifies the GABA(A) receptor subunit alpha3. RNA 2007
28533408 RNA editing of drives early tumor invasion and metastasis in familial esophageal cancer. Proc. Natl. Acad. Sci. U.S.A. 2017
28743982 Oesophageal cancer: RNA editing of SLC22A3 mRNAs: causative relevance to familial ESCC? Nat Rev Gastroenterol Hepatol 2017
21620933 Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience 2011
14645909 Chronic hepatitis delta virus infection with genotype IIb variant is correlated with progressive liver disease. J. Gen. Virol. 2003
26398702 Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review). Mol Med Rep 2015
20701360 Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza A virus-infected cells. J. Proteome Res. 2010
25272020 Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages. PLoS ONE 2014
29906476 ADAR1 affects HCV infection by modulating innate immune response. Antiviral Res. 2018
26440892 Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. Cell Rep 2015
24928581 ADAR1: a promising new biomarker for esophageal squamous cell carcinoma? Expert Rev Anticancer Ther 2014
21729523 [Expression of ADAR1 isoforms in murine acute T-ALL leukemia model]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011
21316340 Abnormal expression of ADAR1 isoforms in Chinese pediatric acute leukemias. Biochem. Biophys. Res. Commun. 2011
22684365 Driving transcriptional regulators in melanoma metastasis. Cancer Metastasis Rev. 2012
28199207 Assessing the potential function of ADAR1 in virus-associated sepsis. Front Biosci (Landmark Ed) 2017
23275297 ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc. Natl. Acad. Sci. U.S.A. 2013
26338962 A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme. Oncotarget 2015
27911851 Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration. Oncotarget 2016
23001123 Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat. Genet. 2012
25172485 Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs. J. Immunol. 2014
25456137 The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep 2014
16917490 Ten novel mutations of the ADAR1 gene in Japanese patients with dyschromatosis symmetrica hereditaria. J. Invest. Dermatol. 2007
19651874 Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection. Nucleic Acids Res. 2009
19710021 RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR. J. Biol. Chem. 2009
24905200 An RNA editor, adenosine deaminase acting on double-stranded RNA (ADAR1). J. Interferon Cytokine Res. 2014
17079286 Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection. J. Virol. 2007
25389016 ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity. Retrovirology 2014
23697632 ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas. BMC Cancer 2013
20372915 TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. Acta Neuropathol. 2010
16183555 Excitotoxicity and ALS: what is unique about the AMPA receptors expressed on spinal motor neurons? Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2005
24608178 Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma. PLoS ONE 2014
20637757 Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. Gastroenterology 2010
18306229 Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma. Hepatology 2008
9633945 Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors. Arterioscler. Thromb. Vasc. Biol. 1998
11116209 Effects of a thyromimetic on apolipoprotein B-100 in rats. J. Mol. Endocrinol. 2000
9672068 Distinct promoters induce APOBEC-1 expression in rat liver and intestine. Arterioscler. Thromb. Vasc. Biol. 1998
26051357 High APOBEC3B expression is a predictor of recurrence in patients with low-risk clear cell renal cell carcinoma. Urol. Oncol. 2015
29769310 Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation 2018
30770787 Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents 2019
30760294 Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma 2019
18462347 Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes 2008
28542129 ADAR1-mediated 3' UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response. 2017
30290838 ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 2018
28928239 The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK. 2017
29925690 AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer 2018
30563560 Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer 2018
30583079 Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer 2019
30697154 Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens 2019
17376196 Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes 2007
29617672 Increased RNA Editing May Provide a Source for Autoantigens in Systemic Lupus Erythematosus 2018
12243919 Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes 2002
30945056 ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD 2019