The abnormal RNA editing genes are significantly enriched in three networks based on Ingenuity Pathway Analysis (IPA).

Top Diseases and Functions: Cell-To-Cell Signaling and Interaction, Nervous System Development and Function, Cardiovascular Disease.

Ingenuity Canonical Pathways
Ingenuity Canonical Pathways Ratio Molecules
Glutamate Receptor Signaling 0.0938
Amyotrophic Lateral Sclerosis Signaling 0.05
Gap Junction Signaling 0.028
CREB Signaling in Neurons 0.0221
Calcium Signaling 0.0187
Neuropathic Pain Signaling In Dorsal Horn Neurons 0.0252
Synaptic Long Term Potentiation 0.0224
Synaptic Long Term Depression 0.0159
Serotonin Receptor Signaling 0.0377
Molecular Mechanisms of Cancer 0.00746
Protein Kinase A Signaling 0.00726
dTMP De Novo Biosynthesis 0.0714
Glioblastoma Multiforme Signaling 0.0116
Serotonin and Melatonin Biosynthesis 0.0588
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 0.01
Role of JAK1, JAK2 and TYK2 in Interferon Signaling 0.0417
Sonic Hedgehog Signaling 0.0323
Role of JAK2 in Hormone-like Cytokine Signaling 0.0294
autophagy 0.0152
Basal Cell Carcinoma Signaling 0.0137
Ephrin B Signaling 0.0133
VDR/RXR Activation 0.0127
Antiproliferative Role of Somatostatin Receptor 2 0.0118
IL-3 Signaling 0.0112
Growth Hormone Signaling 0.0112
JAK/Stat Signaling 0.0112
Erythropoietin Signaling 0.0111
FGF Signaling 0.0105
IL-4 Signaling 0.0103
CTLA4 Signaling in Cytotoxic T Lymphocytes 0.0101
STAT3 Pathway 0.00962
TR/RXR Activation 0.00952
Melanocyte Development and Pigmentation Signaling 0.00943
p53 Signaling 0.00901
SAPK/JNK Signaling 0.00901
IGF-1 Signaling 0.00877
VEGF Signaling 0.0087
LXR/RXR Activation 0.00781
Natural Killer Cell Signaling 0.00752
CD28 Signaling in T Helper Cells 0.0073
Renin-Angiotensin Signaling 0.0073
Aryl Hydrocarbon Receptor Signaling 0.0068
Corticotropin Releasing Hormone Signaling 0.00671
D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis 0.00667
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis 0.00667
Phagosome Maturation 0.00645
3-phosphoinositide Degradation 0.00606
D-myo-inositol-5-phosphate Metabolism 0.00592
Acute Phase Response Signaling 0.00562
Mitochondrial Dysfunction 0.00532
Agranulocyte Adhesion and Diapedesis 0.00515
B Cell Receptor Signaling 0.00503
Clathrin-mediated Endocytosis Signaling 0.00476
3-phosphoinositide Biosynthesis 0.00467
Osteoarthritis Pathway 0.00457
Systemic Lupus Erythematosus Signaling 0.00422
Superpathway of Inositol Phosphate Compounds 0.00386
G-Protein Coupled Receptor Signaling 0.00345
Neuroinflammation Signaling Pathway 0.00307
Axonal Guidance Signaling 0.00216
Ingenuity Canonical Biological Processes
Category Disease, Function Annotation p-Value Molecules
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long-term potentiation of brain cells 1.28E-10
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long-term potentiation of brain 1.93E-9
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long-term potentiation of hippocampal cells 3.24E-9
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long-term potentiation 9.34E-9
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long-term potentiation of CA1 neuron 1.04E-8
  • Cardiovascular Disease
Aneurysm 3.34E-7
  • Cellular Assembly and Organization
  • Cellular Function and Maintenance
Depolarization of cellular membrane 3.56E-7
  • Neurological Disease
Movement Disorders 4.01E-7
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Synaptic transmission 7.2E-7
  • Developmental Disorder
  • Skeletal and Muscular Disorders
Hypoplasia of muscle 7.88E-7
  • Psychological Disorders
Major affective disorder 8.84E-7
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long-term potentiation of hippocampal CA1 region 1.06E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Excitatory postsynaptic potential 1.14E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long-term potentiation of hippocampus 1.33E-6
  • Cell Morphology
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Plasticity of synapse 1.51E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Excitatory postsynaptic potential of neurons 2.46E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Neurotransmission 2.97E-6
  • Behavior
Behavior 4.25E-6
  • Cellular Assembly and Organization
  • Cellular Function and Maintenance
Depolarization of plasma membrane 4.33E-6
  • Cardiovascular System Development and Function
Preservation of elastic lamina 4.53E-6
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Arterial aneurysm 5.24E-6
  • Nervous System Development and Function
Dedepression of CA1 neuron 5.77E-6
  • Nervous System Development and Function
Depotentiation of CA1 neuron 5.77E-6
  • Neurological Disease
Progressive neurological disorder 6.48E-6
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
Dementia 6.85E-6
  • Nervous System Development and Function
  • Neurological Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
Abnormal morphology of brain 8.22E-6
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
Behavioral variant frontotemporal dementia 1.04E-5
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Development of vascular lesion 1.07E-5
  • Nervous System Development and Function
  • Neurological Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
Abnormal morphology of cerebral cortex 1.08E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
Seizure disorder 1.09E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
Early-onset encephalopathy 1.32E-5
  • Neurological Disease
  • Psychological Disorders
Major depression 2.31E-5
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
Psoriasis 2.35E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Inhibitory postsynaptic potential 2.43E-5
  • Neurological Disease
  • Psychological Disorders
Bipolar disorder 2.45E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Synaptic transmission of nervous tissue 2.82E-5
  • Organismal Development
Morphology of head 3.28E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Action potential of neurons 3.77E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
Seizures 4.27E-5
  • Nervous System Development and Function
Electrophysiology of nervous system 4.6E-5
  • Cellular Movement
Migration of cells 4.72E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long term depression of neurons 5.16E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long term depression 5.68E-5
  • Nervous System Development and Function
  • Neurological Disease
Abnormal morphology of nervous system 6.01E-5
  • Cell Morphology
Morphology of fibrosarcoma cell lines 6.42E-5
  • Amino Acid Metabolism
  • Small Molecule Biochemistry
Removal of L-glutamic acid 6.42E-5
  • Organismal Development
Development of endocrine gland 6.81E-5
  • Cell Morphology
  • Nervous System Development and Function
  • Tissue Morphology
Morphology of neurons 7.07E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
Abnormality of cerebral cortex 7.31E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Synaptic transmission of cells 8.08E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
AMPA mediated synaptic current 8.8E-5
  • Dermatological Diseases and Conditions
  • Neurological Disease
  • Organismal Injury and Abnormalities
Hyperesthesia 9.56E-5
  • Organismal Development
  • Organismal Injury and Abnormalities
Abnormal morphology of head 1.07E-4
  • Neurological Disease
Cognitive impairment 1.14E-4
  • Skeletal and Muscular System Development and Function
Grip strength 1.33E-4
  • Developmental Disorder
  • Skeletal and Muscular Disorders
Hypoplasia of vascular smooth muscle cells 1.37E-4
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Synaptic transmission of cerebral cortex cells 1.43E-4
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Skeletal and Muscular Disorders
Autosomal recessive early-onset Parkinson disease 1.43E-4
  • Cellular Movement
Cell movement 1.44E-4
  • Cancer
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Neurofibromatosis 1.46E-4
  • Cell Morphology
  • Cellular Function and Maintenance
Transmembrane potential 1.49E-4
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long term depression of synapse 1.55E-4
  • Cell Death and Survival
Apoptosis 1.57E-4
  • Cell Death and Survival
Apoptosis of neurons 1.57E-4
  • Cell Death and Survival
  • Cellular Compromise
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Tissue Morphology
Neurodegeneration of pyramidal neurons 1.67E-4
  • Cancer
  • Organismal Injury and Abnormalities
Head and neck tumor 1.71E-4
  • Cell Morphology
  • Nervous System Development and Function
  • Neurological Disease
  • Tissue Morphology
Abnormal morphology of neurons 1.73E-4
  • Cell Death and Survival
Necrosis 1.84E-4
  • Metabolic Disease
Glucose metabolism disorder 1.89E-4
  • Developmental Disorder
  • Neurological Disease
Mental retardation 1.99E-4
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Aortic aneurysm 2.06E-4
  • Tissue Morphology
Quantity of lymphoma cell lines 2.12E-4
  • Nervous System Development and Function
Morphology of nervous system 2.33E-4
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
Diabetes mellitus 2.5E-4
  • Developmental Disorder
Overgrowth syndrome 2.69E-4
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Long term depression of CA1 neuron 2.71E-4
  • Cellular Development
  • Cellular Growth and Proliferation
Cell proliferation of lymphoma cell lines 2.83E-4
  • Neurological Disease
Progressive motor neuropathy 2.84E-4
  • Cell Death and Survival
Neuronal cell death 2.97E-4
  • Neurological Disease
  • Organismal Injury and Abnormalities
Progressive encephalopathy 3.02E-4
  • Cellular Movement
Cell movement of tumor cell lines 3.04E-4
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Skeletal and Muscular Disorders
Late-onset Parkinson disease 3.22E-4
  • Tissue Morphology
Quantity of tumor cell lines 3.29E-4
  • Cell Death and Survival
Cell death 3.36E-4
  • Cardiovascular Disease
  • Metabolic Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
Cerebral amyloid angiopathy 3.41E-4
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Familial motor neuron disease 3.52E-4
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
Transmigration of phagocytes 4.07E-4
  • Metabolic Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
Alzheimer disease 4.45E-4
  • Cell Death and Survival
  • Neurological Disease
  • Organismal Injury and Abnormalities
Cell death of pyramidal neurons 4.49E-4
  • Cellular Growth and Proliferation
Colony formation of cells 4.57E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Desmoplastic medulloblastoma 4.6E-4
  • Behavior
Abnormal emotional behavior 5.2E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Large cell or anaplastic medulloblastoma 5.26E-4
  • Organismal Injury and Abnormalities
Edema 5.5E-4
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Development of atherosclerotic lesion 5.57E-4
  • Nervous System Development and Function
  • Neurological Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
Abnormal morphology of hippocampus 5.57E-4
  • Organismal Development
Size of body 5.72E-4
  • Cellular Movement
Migration of tumor cell lines 5.83E-4
  • Neurological Disease
  • Skeletal and Muscular Disorders
Neuromuscular disease 6.04E-4
  • Cancer
  • Organismal Injury and Abnormalities
Angiogenesis of malignant tumor 6.16E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Central nervous system cancer 6.42E-4
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
Frontotemporal lobar degeneration or amyotrophic lateral sclerosis 6.46E-4
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
Myelomonocytic leukemia 6.64E-4
  • Cell Death and Survival
Killing of cells 7.79E-4
  • Cellular Development
  • Cellular Growth and Proliferation
Proliferation of leukemia cell lines 8.02E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Glioma 8.3E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Glioma cancer 8.45E-4
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
Lip cancer 8.63E-4
  • Behavior
  • Nervous System Development and Function
Spatial memory 8.79E-4
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Formation of vascular lesion 9.14E-4
  • Dermatological Diseases and Conditions
  • Neurological Disease
  • Organismal Injury and Abnormalities
Hyperalgesia 9.44E-4
  • Psychological Disorders
Anxiety Disorders 9.52E-4
  • Cell Death and Survival
  • Nervous System Development and Function
Cell viability of neurons 9.71E-4
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Early infantile epileptic encephalopathy type 41 0.001
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Peripheral vascular disease 0.00101
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
Malignant epithelial ovarian tumor 0.00103
  • Behavior
Learning 0.00104
  • Tissue Development
Formation of gland 0.00107
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
Oral tumor 0.00107
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Choroid plexus tumor 0.00111
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Synaptic transmission of pyramidal neurons 0.00112
  • Behavior
Emotional behavior 0.00117
  • Cell Death and Survival
  • Cell Morphology
  • Nervous System Development and Function
  • Organ Morphology
  • Organismal Development
Loss of cerebral cortex cells 0.00119
  • Cell-To-Cell Signaling and Interaction
Aggregation of cervical cancer cell lines 0.0012
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Anaplastic medulloblastoma 0.0012
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
Apoptosis of Burkitt lymphoma cells 0.0012
  • Cancer
  • Connective Tissue Disorders
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
Autosomal dominant Neurofibromatosis-Noonan syndrome 0.0012
  • Cancer
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Autosomal dominant familial spinal neurofibromatosis 0.0012
  • Cancer
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Cafe-au-lait macules with pulmonary stenosis 0.0012
  • Cell-To-Cell Signaling and Interaction
  • Cellular Assembly and Organization
  • Nervous System Development and Function
Cell-cell contact of axons 0.0012
  • Cellular Growth and Proliferation
  • Nervous System Development and Function
Colony formation of Schwann cells 0.0012
  • Metabolic Disease
Deficiency of tryptophan 5-monooxygenase 0.0012
  • Embryonic Development
  • Tissue Morphology
Deformation of floor plate 0.0012
  • Nervous System Development and Function
  • Tissue Morphology
Density of GABAergic neurons 0.0012
  • Inflammatory Response
Fibroinflammatory response 0.0012
  • Nervous System Development and Function
Growth of nerve trunk 0.0012
  • Cellular Movement
Invasion of Schwann cells 0.0012
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Psychological Disorders
Major affective disorder type 1 0.0012
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
Multiple cafe-au-lait spots 0.0012
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Tissue Morphology
Pseudarthrosis 0.0012
  • Nervous System Development and Function
  • Tissue Morphology
Quantity of type-2 astrocytes 0.0012
  • Cellular Movement
Segregation of thalamic cells 0.0012
  • Cellular Assembly and Organization
Stabilization of sarcolemma 0.0012
  • Neurological Disease
  • Psychological Disorders
Susceptibility to attention deficit-hyperactivity disorder type 7 0.0012
  • Cancer
Transformation of pancreatic cancer cell lines 0.0012
  • Cellular Function and Maintenance
Turnover of myofiber 0.0012
  • Cell Morphology
Morphology of sarcoma cell lines 0.00122
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Familial mental retardation 0.00123
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
T acute lymphoblastic leukemia 0.00132
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hypersensitivity Response
  • Inflammatory Response
  • Lymphoid Tissue Structure and Development
Proliferation of mast cells 0.00132
  • Cell Cycle
Interphase of lymphoma cell lines 0.00137
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
Advanced stage psoriasis 0.0014
  • Cell Cycle
Arrest in G1 phase of endometrial stromal cells 0.0014
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Autosomal recessive mental retardation type 6 0.0014
  • Neurological Disease
  • Organismal Injury and Abnormalities
Degeneration of nigrostriatum 0.0014
  • Cell Death and Survival
  • Cell Morphology
  • Nervous System Development and Function
  • Neurological Disease
  • Tissue Morphology
Loss of hilar interneurons 0.0014
  • Cell-To-Cell Signaling and Interaction
  • Cellular Function and Maintenance
  • Nervous System Development and Function
Paired-pulse facilitation of mossy fiber cells 0.0014
  • Cardiac Stenosis
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Retinal arterial macroaneurysm with supravalvular pulmonic stenosis 0.0014
  • Nervous System Development and Function
Sensation 0.0014
  • Embryonic Development
  • Organismal Development
Development of head 0.00141
  • Neurological Disease
  • Organismal Injury and Abnormalities
Degeneration of brain 0.00141
  • Cell Death and Survival
Cell viability of central nervous system cells 0.00143
  • Neurological Disease
Tremor 0.00145
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
Cell viability of leukemia cells 0.00147
  • Cancer
  • Organismal Injury and Abnormalities
Angiogenesis of tumor 0.00147
  • Nervous System Development and Function
  • Tissue Morphology
Quantity of astrocytes 0.00149
  • Organismal Injury and Abnormalities
  • Tissue Morphology
Volume of lesion 0.00151
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Formation of aneurysm 0.00153
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
Proliferation of hematopoietic progenitor cells 0.00155
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
Acute monocytic leukemia (M5) 0.00157
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Development of primitive neuroectodermal tumor 0.00158
  • Behavior
  • Nervous System Development and Function
Memory 0.00158
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
AIDS-related primary CNS lymphoma 0.0016
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
Acute eosinophilic leukemia 0.0016
  • Cell Death and Survival
Anoikis of hepatoma cell lines 0.0016
  • Cell Death and Survival
  • Embryonic Development
Apoptosis of metanephric blastema 0.0016
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
Autosomal dominant chronic kidney disease 0.0016
  • Nucleic Acid Metabolism
  • Small Molecule Biochemistry
Biosynthesis of thymidine 0.0016
  • Infectious Diseases
Chancroid 0.0016
  • Cell Death and Survival
  • Small Molecule Biochemistry
Cytotoxicity of methotrexate 0.0016
  • Cellular Development
  • Embryonic Development
  • Organismal Development
  • Tissue Development
Differentiation of gubernaculum 0.0016
  • Hereditary Disorder
  • Kidney Failure
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
Frasier syndrome 0.0016
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
Glomerulosclerosis of mesangium 0.0016
  • Inflammatory Disease
  • Ophthalmic Disease
  • Organismal Injury and Abnormalities
Inclusion conjunctivitis 0.0016
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
Invasive hydatidiform mole 0.0016
  • Developmental Disorder
Meacham syndrome 0.0016
  • Cardiovascular Disease
  • Hematological Disease
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
Megaloblastic anemia due to dihydrofolate reductase deficiency 0.0016
  • Infectious Diseases
  • Inflammatory Disease
  • Inflammatory Response
  • Neurological Disease
Meningococcal meningitis 0.0016
  • Hereditary Disorder
  • Nephrosis
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
Nephrotic syndrome type 4 0.0016
  • Amino Acid Metabolism
  • Drug Metabolism
  • Small Molecule Biochemistry
  • Vitamin and Mineral Metabolism
Reduction of folic acid 0.0016
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
Refractory psoriasis 0.0016
  • Connective Tissue Disorders
  • Immunological Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
Severe juvenile rheumatoid arthritis 0.0016
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
  • Immune Cell Trafficking
Tethering of lymphocytes 0.0016
  • Hematological Disease
  • Infectious Diseases
Vivax malaria 0.0016
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
WT1-related Wilms tumorigenesis 0.0016
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
Wilms tumor 1 0.0016
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
X-linked mental retardation type 94 0.0016
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
Disorder of basal ganglia 0.00162
  • Embryonic Development
  • Endocrine System Development and Function
  • Organ Development
  • Organismal Development
  • Tissue Development
Formation of adrenal gland 0.00163
  • Psychological Disorders
Hyperactive behavior 0.0017
  • Neurological Disease
  • Organismal Injury and Abnormalities
Epilepsy 0.0017
  • Behavior
Hyperactivity 0.00175
  • Cellular Development
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Skeletal and Muscular System Development and Function
  • Tissue Development
Formation of osteoclasts 0.00175
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
Antagonization of T lymphocytes 0.0018
  • Connective Tissue Disorders
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
Au-Kline syndrome 0.0018
  • Cellular Compromise
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
Calcification of skeletal muscle cells 0.0018
  • Post-Translational Modification
Hyperphosphorylation of protein 0.0018
  • Cellular Movement
Invasion of brain cancer cell lines 0.0018
  • Cellular Growth and Proliferation
Termination of proliferation of cells 0.0018
  • Cancer
  • Organismal Injury and Abnormalities
Cancer of secretory structure 0.00182
  • Cell Death and Survival
Cell death of tumor cell lines 0.00187
  • Organismal Survival
Organismal death 0.00189
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Abdominal aortic aneurysm 0.00192
  • Behavior
Ingestion of ethanol 0.00196
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Inhibitory postsynaptic current 0.00197
  • Antimicrobial Response
Aggregation of rhinovirus 0.002
  • Antigen Presentation
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
  • Humoral Immune Response
  • Inflammatory Response
Antigen presentation of B lymphocytes 0.002
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Atherosclerosis of abdominal aorta 0.002
  • Nervous System Development and Function
Calcium permeability of neurons 0.002
  • Carbohydrate Metabolism
  • Drug Metabolism
  • Small Molecule Biochemistry
Circulation of daunorubicin 0.002
  • Infectious Diseases
Internalization of Hepatitis C virus 0.002
  • Cellular Assembly and Organization
  • Cellular Compromise
  • Nervous System Development and Function
Retraction of glial cell projections 0.002
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Tissue Morphology
  • Tumor Morphology
Size of brain tumor 0.002
  • Endocrine System Disorders
  • Metabolic Disease
Metabolic syndrome X 0.00202
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Astrocytoma 0.00208
  • Nutritional Disease
Obesity 0.00209
  • Cell-mediated Immune Response
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
Transmigration of T lymphocytes 0.00209
  • Cell Death and Survival
Apoptosis of tumor cell lines 0.00216
  • Organ Morphology
Abnormal morphology of gland 0.00218
  • Embryonic Development
  • Nervous System Development and Function
  • Organ Development
  • Organ Morphology
  • Organismal Development
  • Tissue Development
  • Visual System Development and Function
Morphogenesis of camera-type eye 0.00218
  • Organismal Injury and Abnormalities
Organ Degeneration 0.00219
  • Cancer
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
Angiogenesis of pancreatic endocrine tumor 0.0022
  • Cancer
  • Cell Cycle
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Organismal Injury and Abnormalities
  • Tumor Morphology
Contact growth inhibition of medulloblastoma cells 0.0022
  • Cell Death and Survival
Killing of Staphylococcus aureus subsp. aureus str. Newman 0.0022
  • Infectious Diseases
  • Neurological Disease
Rabies 0.0022
  • Cardiovascular Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
Inflammation of blood vessel 0.0022
  • Embryonic Development
  • Nervous System Development and Function
  • Organ Development
  • Organismal Development
  • Tissue Development
Development of spinal cord 0.00221
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
Synaptic transmission of synapse 0.00224
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
Transmigration of monocytes 0.00228
  • Embryonic Development
  • Nervous System Development and Function
  • Organ Development
  • Organismal Development
  • Tissue Development
Development of cerebral cortex 0.00231
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
Cervical cancer 0.00233
  • Cellular Movement
Invasion of tumor cell lines 0.00235
  • Nervous System Development and Function
  • Tissue Morphology
Density of dopaminergic neurons 0.0024
  • Connective Tissue Development and Function
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Skeletal and Muscular System Development and Function
  • Tissue Development
Formation of metatarsal bone 0.0024
  • Vitamin and Mineral Metabolism
Metabolism of dihydrofolate 0.0024
  • Embryonic Development
Regression of notochord 0.0024
  • Dermatological Diseases and Conditions
  • Metabolic Disease
  • Organismal Injury and Abnormalities
Xanthoma 0.0025
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
Ovarian cancer 0.00251
  • Neurological Disease
  • Psychological Disorders
Obsessive-compulsive disorder 0.00254
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Central nervous system solid tumor 0.00255
  • Behavior
Social exploration 0.00258
  • Cellular Development
  • Connective Tissue Development and Function
  • Tissue Development
Differentiation of perichondrial cells 0.0026
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
Diabetic nephropathy 0.00261
  • Protein Synthesis
Quantity of ldl cholesterol in blood 0.00274
  • Cell Death and Survival
  • Nervous System Development and Function
Cell viability of cortical neurons 0.00278
  • Developmental Disorder
  • Embryonic Development
  • Organismal Development
  • Tissue Morphology
Abnormal morphology of gonadal ridge 0.0028
  • Cell-To-Cell Signaling and Interaction
Activation of bone cancer cell lines 0.0028
  • Cell-To-Cell Signaling and Interaction
  • Cellular Assembly and Organization
  • Nervous System Development and Function
Cell-cell contact of Schwann cells 0.0028
  • Dermatological Diseases and Conditions
  • Infectious Diseases
  • Organismal Injury and Abnormalities
Complicated skin and skin structure infection 0.0028
  • Cellular Growth and Proliferation
Cytostasis of endometrial cancer cell lines 0.0028
  • Cell Cycle
Delay in G1 phase of lymphoma cell lines 0.0028
  • Tissue Development
Development of mesothelium 0.0028
  • Amino Acid Metabolism
  • Small Molecule Biochemistry
Inactivation of L-glutamic acid 0.0028
  • Cancer
  • Neurological Disease
  • Ophthalmic Disease
  • Organismal Injury and Abnormalities
Optic nerve glioma 0.0028
  • Cancer
  • Organismal Injury and Abnormalities
Extraadrenal retroperitoneal tumor 0.00282
  • Vitamin and Mineral Metabolism
Quantity of mineral 0.00283
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
Type M2 acute myeloid leukemia 0.00288
  • Nervous System Development and Function
Nociception 0.00289
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
Cecum adenocarcinoma 0.00293
  • Cancer
  • Organismal Injury and Abnormalities
ALK fusion positive solid tumor 0.00295
  • Cellular Assembly and Organization
  • Cellular Function and Maintenance
  • Organ Morphology
  • Skeletal and Muscular System Development and Function
  • Tissue Morphology
Quantity of smooth muscle cells 0.00295
  • Cancer
  • Organismal Injury and Abnormalities
Neoplasia of cells 0.00295
  • Cell Death and Survival
Apoptosis of splenocytes 0.00296
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
Tourette syndrome 0.00296
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
Chronic myeloid leukemia 0.00299
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Growth of glioma 0.00299
  • Auditory Disease
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
Bilateral vestibular schwannoma 0.003
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
Colony formation of LSK cells 0.003
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Renal and Urological System Development and Function
  • Tissue Development
Development of renal calyx 0.003
  • Hereditary Disorder
  • Immunological Disease
  • Organismal Injury and Abnormalities
Familial hemophagocytic lymphohistiocytosis type 2 0.003
  • Cell-mediated Immune Response
  • Lymphoid Tissue Structure and Development
Frequency of central memory cytotoxic T cells 0.003
  • Cell-mediated Immune Response
  • Lymphoid Tissue Structure and Development
Frequency of effector memory helper T cells 0.003
  • Amino Acid Metabolism
  • Small Molecule Biochemistry
Influx of amino acids 0.003
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
Lipid core of atherosclerotic plaque 0.003
  • Connective Tissue Development and Function
  • Tissue Morphology
Quantity of fibrocartilage 0.003
  • Tissue Development
Remodeling of stroma 0.003
  • Embryonic Development
  • Organ Development
  • Organ Morphology
  • Organismal Development
  • Renal and Urological System Development and Function
  • Tissue Development
Size of renal medulla 0.003
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Nutritional Disease
  • Ophthalmic Disease
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
WAGR syndrome with obesity 0.003
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
Type M4 acute myeloid leukemia 0.003
  • Cancer
  • Cardiovascular Disease
  • Hematological Disease
  • Organismal Injury and Abnormalities
Refractory anemia with excess blasts 0.00303
  • Neurological Disease
Dyskinesia 0.00303
  • Dermatological Diseases and Conditions
  • Neurological Disease
  • Organismal Injury and Abnormalities
Allodynia 0.00309
  • Behavior
Spatial learning 0.00313
  • Cancer
  • Organismal Injury and Abnormalities
ALK mutation positive malignant solid tumor 0.00314
  • Organ Morphology
  • Renal and Urological System Development and Function
Quantity of nephron 0.00318
  • Cell-To-Cell Signaling and Interaction
Activation of sarcoma cell lines 0.0032
  • Glomerular Injury
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
Diffuse mesangial sclerosis 0.0032
  • Cancer
  • Hematological Disease
  • Hereditary Disorder
  • Immunological Disease
  • Organismal Injury and Abnormalities
Familial juvenile myelomonocytic leukemia 0.0032
  • Cell Cycle
Senescence of lymphoma cell lines 0.0032
  • Cell Death and Survival
  • Cell Morphology
  • Nervous System Development and Function
  • Neurological Disease
  • Tissue Morphology
Loss of neurons 0.00322
  • Cardiac Hemorrhaging
  • Cardiovascular Disease
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
Bleeding of pericardium 0.00539
  • Cell Death and Survival
  • Renal Necrosis/Cell Death
  • Renal and Urological System Development and Function
Cell viability of kidney cell lines 0.00787
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
Experimental crescentic glomerulonephritis 0.00797
  • Increased Levels of Alkaline Phosphatase
Increased activation of alkaline phosphatase 0.00819
  • Cell Morphology
  • Glomerular Injury
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
Abnormal morphology of mesangial cells 0.00857
  • Gastrointestinal Disease