Basic Information

Enzyme
Full Name
Location
Ensembl
Aliases

Disease Related Information

Disease Species Regulator Expression/Aberrance Target Target Function Regulation Editing-Level Relationship Correlation Editing Effect Phenotype Editing-Dependent PMID
Hepatocellular Carcinoma Human NA Decrease apoB mRNA NA The low-level expression results in sufficient APOBEC-1 to edit essentially all apoB mRNA at the normal editing site, while intermediate (I-20) or high (I-28) levels expression results in hyperediting at multiple sites. Decreased Correlated Negative Hepatic expression of apolipoprotein (apo) B mRNA lowers plasma LDL levels. Inhibit liver dysplasia and hepatocellular carcinoma Yes