NeuroPedia Edit

Citations: 18

z-index: 2.57

Basic information
Short name NeuroPedia
Full name Neuropeptide Database
Description NeuroPedia is a neuropeptide database and spectral library.
URL http://proteomics.ucsd.edu/Software/NeuroPedia/
Year founded 2011
Last update & version 2014-04-16 v1.0
Availability Free to all users
Contact information
University/Institution hosted University of California San Diego
Address La Jolla, California 92093-0744, USA
City San Diego
Province/State CA
Country/Region United States
Contact name Bandeira N
Contact email bandeira@ucsd.edu
Data information
Object(s)
  • Animal
Data type(s)
  • Protein
Data Category/Categories
  • Gene genome and annotation
Major organism(s)
  • NA
Keyword(s)
  • neuropeptide
  • tandem mass spectrometry (MS/MS)
Publications
  • NeuroPedia: neuropeptide database and spectral library.[PMID: 21821666]
    Yoona Kim, Steven Bark, Vivian Hook, Nuno Bandeira

    Neuropeptides are essential for cell-cell communication in neurological and endocrine physiological processes in health and disease. While many neuropeptides have been identified in previous studies, the resulting data has not been structured to facilitate further analysis by tandem mass spectrometry (MS/MS), the main technology for high-throughput neuropeptide identification. Many neuropeptides are difficult to identify when searching MS/MS spectra against large protein databases because of their atypical lengths (e.g. shorter/longer than common tryptic peptides) and lack of tryptic residues to facilitate peptide ionization/fragmentation. NeuroPedia is a neuropeptide encyclopedia of peptide sequences (including genomic and taxonomic information) and spectral libraries of identified MS/MS spectra of homolog neuropeptides from multiple species. Searching neuropeptide MS/MS data against known NeuroPedia sequences will improve the sensitivity of database search tools. Moreover, the availability of neuropeptide spectral libraries will also enable the utilization of spectral library search tools, which are known to further improve the sensitivity of peptide identification. These will also reinforce the confidence in peptide identifications by enabling visual comparisons between new and previously identified neuropeptide MS/MS spectra. http://proteomics.ucsd.edu/Software/NeuroPedia.html bandeira@ucsd.edu Supplementary materials are available at Bioinformatics online.

    Bioinformatics (Oxford, England) 2011:27(19)

    18 Citations (from Europe PMC, 2018-06-22)

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Record metadata

  • Created on: 2015-07-01
    • Zhang Zhang [2016-04-26]
    • Li Mengwei [2015-06-30]
    • Yang Li [2015-11-24]
    • Liu Lin [2016-03-28]
    • Liu Lin [2016-04-17]
    • Ma Lina [2018-06-14]

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