a catalog of biological databases
|Description:||This website is designed as a portal of information regarding transcription factor (TF) activity in the developing B and T cells (lymphocytes) in the mouse.|
|University/Institution:||Indiana University-Purdue University Indianapolis|
|Contact name (PI/Team):||N B Perumal|
|Contact email (PI/Helpdesk):||firstname.lastname@example.org|
LymphTF-DB: a database of transcription factors involved in lymphocyte development. [PMID: 17361201]
B and T cells develop following a similar early stepwise progression to later stages where multiple developmental options are available. These developmental regimes necessitate differential gene expression regulated by a large number of transcription factors (TFs). The resultant burgeoning amount of information has opened a knowledge gap between TF activities during lymphocyte development and a researcher's experiments. We have created the LymphTF database (DB) to fill this gap. This DB holds interactions between individual TFs and their specific targets at a given developmental time. By storing such interactions as a function of developmental progression, we hope to advance the elucidation of regulatory networks that guide lymphocyte development. Besides queries for TF-target gene interactions in developmental stages, the DB provides a graphical representation of downloadable target gene regulatory sequences with locations of the transcriptional start sites and TF-binding sites. The LymphTF-DB can be accessed freely on the web at http://www.iupui.edu/~tfinterx/.