Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database information

LymphTF-DB (B and T Lymphocyte Transcription Factor Activity in Mouse)

General information

Description: This website is designed as a portal of information regarding transcription factor (TF) activity in the developing B and T cells (lymphocytes) in the mouse.
Year founded: 2007
Last update:
Version:
Accessibility:
Manual:
Accessible
Real time : Checking...
Country/Region: United States
Data type:
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Keywords:

Contact information

University/Institution: Indiana University-Purdue University Indianapolis
Address:
City: Indianapolis
Province/State: IN
Country/Region: United States
Contact name (PI/Team): N B Perumal
Contact email (PI/Helpdesk): nperumal@iupui.edu

Record metadata

Created on: 2019-07-01
Curated by:
Lina Ma [2019-07-01]

Ranking

All databases:
4134/4666 (11.423%)
Interaction:
625/691 (9.696%)
4134
Total Rank
6
Citations
0.462
z-index

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Publications

17361201
LymphTF-DB: a database of transcription factors involved in lymphocyte development. [PMID: 17361201]
Childress PJ, Fletcher RL, Perumal NB.

B and T cells develop following a similar early stepwise progression to later stages where multiple developmental options are available. These developmental regimes necessitate differential gene expression regulated by a large number of transcription factors (TFs). The resultant burgeoning amount of information has opened a knowledge gap between TF activities during lymphocyte development and a researcher's experiments. We have created the LymphTF database (DB) to fill this gap. This DB holds interactions between individual TFs and their specific targets at a given developmental time. By storing such interactions as a function of developmental progression, we hope to advance the elucidation of regulatory networks that guide lymphocyte development. Besides queries for TF-target gene interactions in developmental stages, the DB provides a graphical representation of downloadable target gene regulatory sequences with locations of the transcriptional start sites and TF-binding sites. The LymphTF-DB can be accessed freely on the web at http://www.iupui.edu/~tfinterx/.

Genes Immun. 2007:8(4) | 6 Citations (from Europe PMC, 2020-08-15)