ImmunoSPDB Edit

Citations: 0

z-index: 0

Basic information
Short name ImmunoSPDB
Full name
Description ImmunoSPdb is a repository of experimentally validated peptides which suppress the immune system. All information compiled in this database has been extracted from research papers and patents.
Year founded
Last update & version
Accessibility Accessible
Contact information

The contact information is provided to facilitate update of database information, and it is curated based on the contact details in the database or the related publications. To ensure effective contact with database constructors, we give priority to the contact details in the database.

University/Institution Indraprastha Institute of Information Technology
Country/Region India
Contact name (PI/Team) Gajendra P. S. Raghava
Contact email (PI/Helpdesk)
Data information
Data object
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  • ImmunoSPdb: an archive of immunosuppressive peptides. [PMID: 30753476]
    Usmani SS, Agrawal P, Sehgal M, Patel PK, Raghava GPS.

    Immunosuppression proved as a captivating therapy in several autoimmune disorders, asthma as well as in organ transplantation. Immunosuppressive peptides are specific for reducing efficacy of immune system with wide range of therapeutic implementations. `ImmunoSPdb' is a comprehensive, manually curated database of around 500 experimentally verified immunosuppressive peptides compiled from 79 research article and 32 patents. The current version comprises of 553 entries providing extensive information including peptide name, sequence, chirality, chemical modification, origin, nature of peptide, its target as well as mechanism of action, amino acid frequency and composition, etc. Data analysis revealed that most of the immunosuppressive peptides are linear (91%), are shorter in length i.e. up to 20 amino acids (62%) and have L form of amino acids (81%). About 30% peptide are either chemically modified or have end terminal modification. Most of the peptides either are derived from proteins (41%) or naturally (27%) exist. Blockage of potassium ion channel (24%) is one a major target for immunosuppressive peptides. In addition, we have annotated tertiary structure by using PEPstrMOD and I-TASSER. Many user-friendly, web-based tools have been integrated to facilitate searching, browsing and analyzing the data. We have developed a user-friendly responsive website to assist a wide range of users.

    Database (Oxford) 2019:2019()

    0 Citations (from Europe PMC, 2019-07-27)


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  • Created on: 2019-05-29
    • ***ina@*** [2019-05-29]

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